Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning

Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning

Abstract Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder, yet its underlying molecular mechanisms remain puzzling. This study aimed to uncover the genes with a causal relationship to KOA using Mendelian randomization (MR), transcriptomic profiling, and machine learning methods....

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Bibliographic Details
Main Authors: Bing Ma, Xiaoru Wang, Chengfei Xu, Zelin Xu, Fei Zhang, Wendan Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Knee osteoarthritis
MEG3
MAPK3
Mendelian randomization
EQTL
Online Access:https://doi.org/10.1038/s41598-025-06175-7
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https://doi.org/10.1038/s41598-025-06175-7

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