Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis
Introduction. Aim of this study is to determine if HbA1c levels are a reliable predictor of glycemic control in patients with decompensated cirrhosis. Methods. 200 unique patients referred for liver transplantation at University of Tennessee/Methodist University Transplant Institute with a HbA1c res...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/8390210 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850233333093498880 |
|---|---|
| author | Jeffrey Nadelson Sanjaya K. Satapathy Satheesh Nair |
| author_facet | Jeffrey Nadelson Sanjaya K. Satapathy Satheesh Nair |
| author_sort | Jeffrey Nadelson |
| collection | DOAJ |
| description | Introduction. Aim of this study is to determine if HbA1c levels are a reliable predictor of glycemic control in patients with decompensated cirrhosis. Methods. 200 unique patients referred for liver transplantation at University of Tennessee/Methodist University Transplant Institute with a HbA1c result were included. Three glucose levels prior to the “measured” A1c (MA1c) were input into an HbA1c calculator from the American Diabetes Association website to determine the “calculated” A1c (CA1c). The differences between MA1c and CA1c levels were computed. Patients were divided into three groups: group A, difference of <0.5; group B, 0.51–1.5; and group C, >1.5. Results. 97 (49%) patients had hemoglobin A1c of less than 5%. Discordance between calculated and measured HbA1c of >0.5% was seen in 47% (n=94). Higher level of discordance of greater than >1.5 was in 12% of patients (n=24). Hemoglobin was an independent predictor for higher discordance (odds ratio 0.77 95%, CI 0.60–0.99, and p value 0.04). HbA1c was an independent predictor of occurrence of HCC (OR 2.69 955, CI 1.38–5.43, and p value 0.008). Conclusion. HbA1c is not a reliable predictor of glycemic control in patients with decompensated cirrhosis, especially in those with severe anemia. |
| format | Article |
| id | doaj-art-03245b29d7174ba8920be1f94de7f04c |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-03245b29d7174ba8920be1f94de7f04c2025-08-20T02:02:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/83902108390210Glycated Hemoglobin Levels in Patients with Decompensated CirrhosisJeffrey Nadelson0Sanjaya K. Satapathy1Satheesh Nair2Division of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, Memphis, TN, USAMethodist Transplant Institute, Division of Surgery, University of Tennessee Health Sciences Center, Memphis, TN, USAMethodist Transplant Institute, Division of Surgery, University of Tennessee Health Sciences Center, Memphis, TN, USAIntroduction. Aim of this study is to determine if HbA1c levels are a reliable predictor of glycemic control in patients with decompensated cirrhosis. Methods. 200 unique patients referred for liver transplantation at University of Tennessee/Methodist University Transplant Institute with a HbA1c result were included. Three glucose levels prior to the “measured” A1c (MA1c) were input into an HbA1c calculator from the American Diabetes Association website to determine the “calculated” A1c (CA1c). The differences between MA1c and CA1c levels were computed. Patients were divided into three groups: group A, difference of <0.5; group B, 0.51–1.5; and group C, >1.5. Results. 97 (49%) patients had hemoglobin A1c of less than 5%. Discordance between calculated and measured HbA1c of >0.5% was seen in 47% (n=94). Higher level of discordance of greater than >1.5 was in 12% of patients (n=24). Hemoglobin was an independent predictor for higher discordance (odds ratio 0.77 95%, CI 0.60–0.99, and p value 0.04). HbA1c was an independent predictor of occurrence of HCC (OR 2.69 955, CI 1.38–5.43, and p value 0.008). Conclusion. HbA1c is not a reliable predictor of glycemic control in patients with decompensated cirrhosis, especially in those with severe anemia.http://dx.doi.org/10.1155/2016/8390210 |
| spellingShingle | Jeffrey Nadelson Sanjaya K. Satapathy Satheesh Nair Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis International Journal of Endocrinology |
| title | Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis |
| title_full | Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis |
| title_fullStr | Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis |
| title_full_unstemmed | Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis |
| title_short | Glycated Hemoglobin Levels in Patients with Decompensated Cirrhosis |
| title_sort | glycated hemoglobin levels in patients with decompensated cirrhosis |
| url | http://dx.doi.org/10.1155/2016/8390210 |
| work_keys_str_mv | AT jeffreynadelson glycatedhemoglobinlevelsinpatientswithdecompensatedcirrhosis AT sanjayaksatapathy glycatedhemoglobinlevelsinpatientswithdecompensatedcirrhosis AT satheeshnair glycatedhemoglobinlevelsinpatientswithdecompensatedcirrhosis |