Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade

Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade

Abstract Background Mitochondrial dysfunction emerges as an early pathological hallmark of Alzheimer's disease (AD). The reduction in mitochondrial membrane potential and the elevation of reactive oxygen species (ROS) production are pivotal in the initiation of neuronal cell apoptosis. Peduncul...

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Bibliographic Details
Main Authors: Liwei Li, Jinfeng Sun, Fan Chen, Li Xiong, Lingyu She, Tang Hao, Yuqing Zeng, Luyao Li, Wei Wang, Xia Zhao, Guang Liang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Chinese Medicine
Subjects:
Alzheimer’s disease
Pedunculoside
3 × Tg-AD mice
Oxidative stress
Apoptosis
Online Access:https://doi.org/10.1186/s13020-024-01033-6
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https://doi.org/10.1186/s13020-024-01033-6

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