Evaluation of representativeness and sustainability of PCOS rat models induced by letrozole with or without high-fat diet

Abstract This article aimed to evaluate the representativeness and sustainability of a rat model of polycystic ovary syndrome (PCOS) induced by letrozole (LE) with or without a high-fat diet (HFD). Sexually mature SD rats were randomly divided into a sham group (receiving 1% carboxymethyl cellulose...

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Bibliographic Details
Main Authors: Shanqin Qi, Haiyan Yu, Wen Hu, Dongshuai Xia, Qinghan Shi, Kehua Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-15026-4
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