Hot Melt Extrusion as Continuous Manufacturing Technique to Produce Bilayer Films Loaded with Paracetamol or Lactase

Hot Melt Extrusion as Continuous Manufacturing Technique to Produce Bilayer Films Loaded with Paracetamol or Lactase

<b>Background/Objectives</b>: The oral delivery of large-molecule drugs remains challenging due to poor solubility, perdemeability, and stability in the gastrointestinal tract, resulting in low bioavailability. In this study, hot melt extrusion (HME) was investigated as a solvent-free ma...

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Bibliographic Details
Main Authors: Friederike Brokmann, Katharina Luthe, Jonas Hartmann, Laura Müller, Friederike Klammt, Carla Hoffmann, Werner Weitschies, Christoph Rosenbaum
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
bilayer films
hot melt extrusion
drug delivery
lactase
biorelevant dissolution
mucoadhesion
Online Access:https://www.mdpi.com/1424-8247/18/3/310
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