Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages

Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical regulatory function. Josephin domain containing 2 (JOSD2), a de...

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Bibliographic Details
Main Authors: Xin Liu, Yi Fang, Mincong Huang, Shiliang Tu, Boan Zheng, Hang Yuan, Peng Yu, Mengyao Lan, Wu Luo, Yongqiang Zhou, Guorong Chen, Zhe Shen, Yi Wang, Guang Liang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Colitis
Deubiquitinase
JOSD2
IMPDH2
Inflammation
Inflammatory bowel disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004702
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