Precise identification of viral–host integration events in HPV-positive cervical cancers by targeted long-read sequencing

Precise identification of viral–host integration events in HPV-positive cervical cancers by targeted long-read sequencing

Human papillomaviral (HPV) integrations into host human genome, a frequently observed event in HPV associated cervical cancer, are currently mapped through expensive Whole Genome sequencing (WGS) or RNA sequencing (RNA-seq) methodologies. This study aims to develop a targeted sequencing assay to det...

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Main Authors: Preetiparna Parida, Nivedita Mukherjee, Agastya Singh, Shirley Lewis, Krishna Sharan, Sandeep Mallya, Ashima Singh, Surya Sarathi Das, Mahadev Rao, Daniel S. Higginson, Radhakrishnan Sabarinathan, Rama Rao Damerla
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Tumour Virus Research
Subjects:
HPV integration
Cervical cancer
Nanopore sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679025000138
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http://www.sciencedirect.com/science/article/pii/S2666679025000138

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