LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation

LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation

Upregulation of leucine-rich alpha-2-glycoprotein-1 (LRG1) contributes to aberrant neovascularization in many different diseases. In contrast, LRG1 is not involved in developmental angiogenesis. Here, we investigated the vasculopathic properties of LRG1 by examining its effect on developing retinal...

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Bibliographic Details
Main Authors: Alexandra E. Hoeh, Jui-Hsien Chang, Ronja S. Mueller, Mark Basche, Alessandro Fantin, Anastasios Sepetis, Giulia De Rossi, Athina Dritsoula, Robin R. Ali, Patric Turowski, Stephen E. Moss, John Greenwood
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
leucine-rich alpha-2-glycoprotein-1 (LRG1)
pericyte
blood–retinal barrier
angiogenesis
blood vessel maturation
Online Access:https://www.mdpi.com/2073-4409/14/8/593
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