Advances in Immunotherapy for Melanoma: A Comprehensive Review
Melanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recog...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3264217 |
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| _version_ | 1832548931929636864 |
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| author | Carmen Rodríguez-Cerdeira Miguel Carnero Gregorio Adriana López-Barcenas Elena Sánchez-Blanco Beatriz Sánchez-Blanco Gabriella Fabbrocini Brunilda Bardhi Ardiana Sinani Roberto Arenas Guzman |
| author_facet | Carmen Rodríguez-Cerdeira Miguel Carnero Gregorio Adriana López-Barcenas Elena Sánchez-Blanco Beatriz Sánchez-Blanco Gabriella Fabbrocini Brunilda Bardhi Ardiana Sinani Roberto Arenas Guzman |
| author_sort | Carmen Rodríguez-Cerdeira |
| collection | DOAJ |
| description | Melanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recognize antigens on the surface of cancer cells. Current experimental approaches in immunotherapy include vaccines, biochemotherapy, and the transfer of adoptive T cells and dendritic cells. Several types of vaccines, including peptide, viral, and dendritic cell vaccines, are currently under investigation for the treatment of melanoma. These treatments have the same goal as drugs that are already used to stimulate the proliferation of T lymphocytes in order to destroy tumor cells; however, immunotherapies aim to selectively attack the tumor cells of each patient. In this comprehensive review, we describe recent advancements in the development of immunotherapies for melanoma, with a specific focus on the identification of neoantigens for the prediction of their elicited immune responses. This review is expected to provide important insights into the future of immunotherapy for melanoma. |
| format | Article |
| id | doaj-art-02cf1d0c019942c0950e28fd81f86eee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-02cf1d0c019942c0950e28fd81f86eee2025-02-03T06:12:35ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/32642173264217Advances in Immunotherapy for Melanoma: A Comprehensive ReviewCarmen Rodríguez-Cerdeira0Miguel Carnero Gregorio1Adriana López-Barcenas2Elena Sánchez-Blanco3Beatriz Sánchez-Blanco4Gabriella Fabbrocini5Brunilda Bardhi6Ardiana Sinani7Roberto Arenas Guzman8Dermatology Service, Hospital do Meixoeiro and University of Vigo, Vigo, SpainDepartment of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, SpainMycology Service, Hospital Manuel Gea González, Mexico City, MexicoHealth Department, Xunta Galicia, Vigo, SpainGalician Healthcare Service, Vigo, SpainDermatology Service, University of Napoli Federico II, Naples, ItalyDermatology Service, Venus Clinic, Tirana, AlbaniaDermatology Service, Military Medical Unit, University Trauma Hospital, Tirana, AlbaniaMycology Service, Hospital Manuel Gea González, Mexico City, MexicoMelanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recognize antigens on the surface of cancer cells. Current experimental approaches in immunotherapy include vaccines, biochemotherapy, and the transfer of adoptive T cells and dendritic cells. Several types of vaccines, including peptide, viral, and dendritic cell vaccines, are currently under investigation for the treatment of melanoma. These treatments have the same goal as drugs that are already used to stimulate the proliferation of T lymphocytes in order to destroy tumor cells; however, immunotherapies aim to selectively attack the tumor cells of each patient. In this comprehensive review, we describe recent advancements in the development of immunotherapies for melanoma, with a specific focus on the identification of neoantigens for the prediction of their elicited immune responses. This review is expected to provide important insights into the future of immunotherapy for melanoma.http://dx.doi.org/10.1155/2017/3264217 |
| spellingShingle | Carmen Rodríguez-Cerdeira Miguel Carnero Gregorio Adriana López-Barcenas Elena Sánchez-Blanco Beatriz Sánchez-Blanco Gabriella Fabbrocini Brunilda Bardhi Ardiana Sinani Roberto Arenas Guzman Advances in Immunotherapy for Melanoma: A Comprehensive Review Mediators of Inflammation |
| title | Advances in Immunotherapy for Melanoma: A Comprehensive Review |
| title_full | Advances in Immunotherapy for Melanoma: A Comprehensive Review |
| title_fullStr | Advances in Immunotherapy for Melanoma: A Comprehensive Review |
| title_full_unstemmed | Advances in Immunotherapy for Melanoma: A Comprehensive Review |
| title_short | Advances in Immunotherapy for Melanoma: A Comprehensive Review |
| title_sort | advances in immunotherapy for melanoma a comprehensive review |
| url | http://dx.doi.org/10.1155/2017/3264217 |
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