Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages

Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages

Abstract Adeno-associated virus (AAV)-based gene therapy is emerging as a promising treatment for deafness and vestibular deficits, due to the variety of available serotypes that offer a large range of cell targeting capabilities. Nevertheless, the tropism of these AAV serotypes for sensory inner ea...

Full description

Saved in:
Bibliographic Details
Main Authors: Sepideh Iranfar, Maxence Cornille, Mauricio Saenz Roldan, Baptiste Plion, Marie-José Lecomte, Saaid Safieddine, Ghizlene Lahlou
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Inner ear
Gene therapy
AAV
Serotype
Tropism
Therapeutic time window
Online Access:https://doi.org/10.1038/s41598-025-98007-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-98007-x

Similar Items