Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach

BackgroundPain is a multifaceted condition intricately linked to inflammation, which plays a critical role in its onset and progression.MethodsTo investigate the influence of APE1/Ref-1 on oxidative stress and inflammatory marker expression, we employed a hind paw sensitization model induced by form...

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Bibliographic Details
Main Authors: Eman Elgendy, Amira Zaky, Mayssaa Wahby, Marc Landry, Ahmad Bassiouny
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1542264/full
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