Generation and selection of novel human-neutralizing single chain variable fragments against rabies virus from immunized phage display libraries

Generation and selection of novel human-neutralizing single chain variable fragments against rabies virus from immunized phage display libraries

Rabies remains a deadly infectious disease in tropical areas caused by rabies virus (RABV). Currently, there are limitations in the production and quality control of polyclonal antibodies for postexposure prophylaxis (PEP) for severe patients. Engineered therapeutic monoclonal antibodies (MAbs) are...

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Main Authors: Apidsada Chorpunkul, Usa Boonyuen, Kriengsak Limkittikul, Wachiraporn Saengseesom, Wallaya Phongphaew, Iyarath Putchong, Montarop Yamabhai, Amin Hajitou, Surachet Benjathummarak, Porntippa Lekcharoensuk, Pannamthip Pitaksajjakul, Pongrama Ramasoota
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Heliyon
Subjects:
Glycoprotein
Infectious disease
Molecular docking
Monoclonal antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025013040
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