Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer

Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer

Fusobacterium nucleatum (Fn) is commonly enriched in colorectal cancer (CRC) and associated with poor outcomes, though its mechanisms remain unclear. Our study investigated how Fn affects the tumor microenvironment through single-cell transcriptomic analyses of 42 CRC patient tissues, comparing Fn-p...

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Main Authors: Ilseok Choi, Kyung-A Kim, Sang Cheol Kim, Donghwan Park, Ki Taek Nam, Jun Hyung Cha, Seungbyn Baek, Junha Cha, Hye-Yeong Jo, Minsun Jung, Melody Y. Zeng, Irina Matei, Susan Bullman, Joong Bae Ahn, Yoon Dae Han, Han Sang Kim, Insuk Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Colorectal cancer
Fusobacterium nucleatum
secretory IgA
plasma cell development
tumor bacterial burden
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2528428
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2528428

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