Metabolic parameters on baseline and early [18F]FDG PET/CT as a predictive biomarker for resistance to BRAF/MEK inhibition in advanced cutaneous BRAFV600-mutated melanoma

Metabolic parameters on baseline and early [18F]FDG PET/CT as a predictive biomarker for resistance to BRAF/MEK inhibition in advanced cutaneous BRAFV600-mutated melanoma

Abstract Background [18F]FDG PET/CT plays a crucial role in evaluating cancer patients and assessing treatment response, including in BRAF-mutated melanoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have emerged as promising alternatives to standardized uptake value (SUV)-based...

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Main Authors: Bernies van der Hiel, Berlinda J. de Wit - van der Veen, Alfons J. M. van den Eertwegh, Wouter V. Vogel, Marcel P. M. Stokkel, Marta Lopez-Yurda, Ronald Boellaard, Ellen W. Kapiteijn, Geke A. P. Hospers, Maureen J. B. Aarts, Filip Y. F. L. de Vos, Marye J. Boers-Sonderen, Astrid A. M. van der Veldt, Jan Willem B. de Groot, John B. A. G. Haanen
Format: Article
Language:English
Published: SpringerOpen 2025-05-01
Series:EJNMMI Research
Subjects:
Melanoma
BRAF mutation
Progression-free survival
Positron emission tomography
Metabolic tumor volume
Total lesion glycolysis
Online Access:https://doi.org/10.1186/s13550-025-01259-x
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https://doi.org/10.1186/s13550-025-01259-x

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