Evaluating cell-free DNA integrity index as a non-invasive biomarker for neoadjuvant chemotherapy in colorectal cancer patients

Evaluating cell-free DNA integrity index as a non-invasive biomarker for neoadjuvant chemotherapy in colorectal cancer patients

Abstract Background Neoadjuvant chemotherapy (NAC) is gaining attention as a treatment for advanced colorectal cancer owing to its potential to improve surgical outcomes and prognosis. However, reliable biomarkers to predict the response to NAC are lacking. We aimed to investigate the predictive val...

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Main Authors: Takuma Iwai, Takeshi Yamada, Kay Uehara, Seiichi Shinji, Akihisa Matsuda, Yasuyuki Yokoyama, Goro Takahashi, Toshimitsu Miyasaka, Shintaro Kanaka, Michihiro Koizumi, Hiroshi Yoshida
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Liquid biopsy
Cell-free DNA
Neoadjuvant chemotherapy
Online Access:https://doi.org/10.1186/s12885-025-14570-6
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https://doi.org/10.1186/s12885-025-14570-6

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