Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL

Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL

Lecithin:cholesterol acyltransferase (LCAT) is a high-density lipoprotein (HDL) modifying protein that profoundly affects the composition and function of HDL subspecies. The cholesterol esterification activity of LCAT is dramatically increased by apolipoprotein A-I (APOA1) on HDL, but the mechanism...

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Main Authors: Bethany Coleman, Shimpi Bedi, John H. Hill, Jamie Morris, Kelly A. Manthei, Rachel C. Hart, Yi He, Amy S. Shah, W. Gray Jerome, Tomas Vaisar, Karin E. Bornfeldt, Hyun Song, Jere P. Segrest, Jay W. Heinecke, Stephen G. Aller, John J.G. Tesmer, W. Sean Davidson
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein
apolipoprotein A-I
cholesterol esterification
cross-linking
cryo-electron microscopy
docking
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752500046X
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