Metabolome alterations in pediatric metabolically unhealthy obesity are primarily linked to abnormal glucose homeostasis

Metabolome alterations in pediatric metabolically unhealthy obesity are primarily linked to abnormal glucose homeostasis

Abstract The mechanisms underlying metabolically healthy obesity (MHO) in pediatrics remain poorly understood. This study aims to evaluate the plasma metabolome of MHO versus metabolically unhealthy obesity (MUO) in Asian children and adolescents, to identify key metabolic drivers that undergird the...

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Main Authors: Daniel Zhi Wei Ng, Yu Hao Shie, Sandheep Ransilu Piyasanka, Dorinda Yan Qin Kioh, Andrew Anjian Sng, Bee Wah Lee, Yung Seng Lee, Eric Chun Yong Chan, Delicia Shu Qin Ooi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Abnormal glucose tolerance
Children and adolescents with obesity
Metabolically healthy obesity
Metabolically unhealthy obesity
Metabolic syndrome
Plasma metabolomics
Online Access:https://doi.org/10.1038/s41598-025-09132-6
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https://doi.org/10.1038/s41598-025-09132-6

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