Influence of mode of delivery on infant gut microbiota composition: a pilot study
Background Microbial colonisation in infants is initially dependent on the mother and is affected by the mode of delivery. Understanding these impacts is crucial as the early-life gut microbiota plays a vital role in immune development, metabolism, and overall health. Early-life infant gut microbiot...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2368829 |
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| author | Li Yu Yong Guo Jie-Ling Wu |
| author_facet | Li Yu Yong Guo Jie-Ling Wu |
| author_sort | Li Yu |
| collection | DOAJ |
| description | Background Microbial colonisation in infants is initially dependent on the mother and is affected by the mode of delivery. Understanding these impacts is crucial as the early-life gut microbiota plays a vital role in immune development, metabolism, and overall health. Early-life infant gut microbiota is diverse among populations and geographic origins. However, in this context, only a few studies have explored the impact of the mode of delivery on the intestinal microbiome in children in Guangzhou, China. Therefore, this study aimed to investigate the influence of birth mode on the intestinal microbiota of healthy infants in Guangzhou, China.Methods Faecal samples were collected once from 20 healthy full-term infants aged 1–6 months, delivered via either caesarean section (CS) or vaginal delivery (VD), post-enrolment. The intestinal microbiota were characterised using full-length 16S rRNA gene sequencing. Bacterial quantity and community composition were compared between the two groups.Results No significant differences in gut bacterial diversity and richness were observed between the CS and VD groups. The Pseudomonadota phylum (44.15 ± 33.05% vs 15.62 ± 15.60%, p = 0.028) and Enterobacteriaceae family (44.00 ± 33.11% vs 15.31 ± 15.47%, p = 0.028) were more abundant in the CS group than in the VD group. The VD group exhibited a higher abundance of the Bacillota phylum (40.51 ± 32.77% vs 75.57 ± 27.83%, p = 0.019),Conclusions The early stage of intestinal bacterial colonisation was altered in the CS group as compared with the VD group. Our findings provide evidence that CS has the potential to disrupt the maturation of intestinal microbial communities in infants by influencing the colonisation of specific microorganisms. Further comprehensive studies that consider geographical locations are necessary to elucidate the progression of microbiota in infants born via different delivery modes. |
| format | Article |
| id | doaj-art-0262386c34834e658c02e3ec7be44b41 |
| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-0262386c34834e658c02e3ec7be44b412025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2368829Influence of mode of delivery on infant gut microbiota composition: a pilot studyLi Yu0Yong Guo1Jie-Ling Wu2Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, ChinaBackground Microbial colonisation in infants is initially dependent on the mother and is affected by the mode of delivery. Understanding these impacts is crucial as the early-life gut microbiota plays a vital role in immune development, metabolism, and overall health. Early-life infant gut microbiota is diverse among populations and geographic origins. However, in this context, only a few studies have explored the impact of the mode of delivery on the intestinal microbiome in children in Guangzhou, China. Therefore, this study aimed to investigate the influence of birth mode on the intestinal microbiota of healthy infants in Guangzhou, China.Methods Faecal samples were collected once from 20 healthy full-term infants aged 1–6 months, delivered via either caesarean section (CS) or vaginal delivery (VD), post-enrolment. The intestinal microbiota were characterised using full-length 16S rRNA gene sequencing. Bacterial quantity and community composition were compared between the two groups.Results No significant differences in gut bacterial diversity and richness were observed between the CS and VD groups. The Pseudomonadota phylum (44.15 ± 33.05% vs 15.62 ± 15.60%, p = 0.028) and Enterobacteriaceae family (44.00 ± 33.11% vs 15.31 ± 15.47%, p = 0.028) were more abundant in the CS group than in the VD group. The VD group exhibited a higher abundance of the Bacillota phylum (40.51 ± 32.77% vs 75.57 ± 27.83%, p = 0.019),Conclusions The early stage of intestinal bacterial colonisation was altered in the CS group as compared with the VD group. Our findings provide evidence that CS has the potential to disrupt the maturation of intestinal microbial communities in infants by influencing the colonisation of specific microorganisms. Further comprehensive studies that consider geographical locations are necessary to elucidate the progression of microbiota in infants born via different delivery modes.https://www.tandfonline.com/doi/10.1080/01443615.2024.2368829Caesarean sectiondelivery modeinfantmicrobiomevaginal delivery16S rRNA gene sequencing |
| spellingShingle | Li Yu Yong Guo Jie-Ling Wu Influence of mode of delivery on infant gut microbiota composition: a pilot study Journal of Obstetrics and Gynaecology Caesarean section delivery mode infant microbiome vaginal delivery 16S rRNA gene sequencing |
| title | Influence of mode of delivery on infant gut microbiota composition: a pilot study |
| title_full | Influence of mode of delivery on infant gut microbiota composition: a pilot study |
| title_fullStr | Influence of mode of delivery on infant gut microbiota composition: a pilot study |
| title_full_unstemmed | Influence of mode of delivery on infant gut microbiota composition: a pilot study |
| title_short | Influence of mode of delivery on infant gut microbiota composition: a pilot study |
| title_sort | influence of mode of delivery on infant gut microbiota composition a pilot study |
| topic | Caesarean section delivery mode infant microbiome vaginal delivery 16S rRNA gene sequencing |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2368829 |
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