Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.

Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.

Wiskott-Aldrich Syndrome protein (WASP) is a key regulator of the actin cytoskeleton in hematopoietic cells. Defective expression of WASP leads to multiple abnormalities in different hematopoietic cells. Despite severe impairment of T cell function, WAS patients exhibit a high prevalence of autoimmu...

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Main Authors: Marita Bosticardo, Silvia Musio, Elena Fontana, Stefano Angiari, Elena Draghici, Gabriela Constantin, Pietro L Poliani, Rosetta Pedotti, Anna Villa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0086942
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https://doi.org/10.1371/journal.pone.0086942

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