Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver

Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver

Abstract Background Tibetan pigs, which have long inhabited the Qinghai-Tibet Plateau at elevations exceeding 3000 m, serve as an ideal model for studying adaptation to extreme high-altitude environments. The multifunctionality of the liver (hematopoiesis, metabolism, detoxification) plays a crucial...

Full description

Saved in:
Bibliographic Details
Main Authors: Xinpeng Li, Xinxing Dong, Shuhong Zhao, Yunlong Ma, Siqi Jin, Chunlu Zhou, Yi Lan, Shuyuan Luo, Bin Ni, Hongjiang Wei, Dawei Yan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
Diqing Tibetan pig
Single-nucleus transcriptome sequencing
Hematopoietic stem cells
Hepatocytes
Hypoxia and cryogenic adaptation
Online Access:https://doi.org/10.1186/s12915-025-02281-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12915-025-02281-0

Similar Items