Efficacy and potential mechanisms of jatrorrhizine on MNNG-induced chronic atrophic gastritis in rats based on serological metabolomics and molecular docking

Efficacy and potential mechanisms of jatrorrhizine on MNNG-induced chronic atrophic gastritis in rats based on serological metabolomics and molecular docking

Abstract Jatrorrhizine (JATR), a natural isoquinoline alkaloid from Coptidis Rhizoma, exhibits various pharmacological activities, including antibacterial, anti-inflammatory, and antitumor effects. While JATR is known to treat chronic gastritis, its therapeutic potential for chronic atrophic gastrit...

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Bibliographic Details
Main Authors: Zong-ge Sha, Sen Lin, Zhi-liang Fan, Ze-Chun Yang, Ye-tao Gong, Tao Qin, Rong Yu, Yong He
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Jatrorrhizine
NL family pyrin domain containing 3
Caspase-3
Chronic atrophic gastritis
MNNG
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-05502-2
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https://doi.org/10.1038/s41598-025-05502-2

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