Astrocyte-derived MMP-9 is a key mediator of pseudorabies virus penetration of the blood–brain barrier and tight junction disruption

Astrocyte-derived MMP-9 is a key mediator of pseudorabies virus penetration of the blood–brain barrier and tight junction disruption

Abstract Pseudorabies virus (PRV) infection leads to viral encephalitis and neurological damage in mice, causing significant neurological symptoms and brain damage. This study aimed to investigate the cellular mechanisms of PRV-induced encephalopathy and the role of matrix metalloproteinase-9 (MMP-9...

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Bibliographic Details
Main Authors: Ying Zhang, Xianghua Shu, Chunlian Song, Yi Wu, Kesi Cui, Xue Zhang, Yalong Sun, Hong Shen, Qianfei Wei, Jianqin Li, Yue Shu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Veterinary Research
Subjects:
Pseudorabies virus
matrix metalloproteinase-9
blood–brain barrier
tight junctions
astrocytes
Online Access:https://doi.org/10.1186/s13567-025-01486-z
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https://doi.org/10.1186/s13567-025-01486-z

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