Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming

Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming

Abstract Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM). Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) for site-specific delivery of therapeutic agents and...

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Bibliographic Details
Main Authors: Yang Chen, Hailong Tian, Xiaodian Zhang, Edouard C. Nice, Canhua Huang, Haiyuan Zhang, Shaojiang Zheng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Glioblastoma multiforme
Blood–brain barrier
Immunotherapy
Cuproptosis
cGAS-STING pathway
Online Access:https://doi.org/10.1186/s12951-024-03059-2
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https://doi.org/10.1186/s12951-024-03059-2

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