A plug-and-play system for polycyclic tetramate macrolactam production and functionalization

A plug-and-play system for polycyclic tetramate macrolactam production and functionalization

Abstract Background The biosynthesis of the natural product family of the polycyclic tetramate macrolactams (PoTeMs) employs an uncommon iterative polyketide synthase/non-ribosomal peptide synthetase (iPKS/NRPS). This machinery produces a universal PoTeM biosynthetic precursor that contains a tetram...

Full description

Saved in:
Bibliographic Details
Main Authors: Anna Glöckle, Sebastian Schuler, Manuel Einsiedler, Tobias A. M. Gulder
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Microbial Cell Factories
Subjects:
Polycyclic tetramate macrolactam
Combinatorial biosynthesis
Natural products
Promoter engineering
Heterologous expression
Online Access:https://doi.org/10.1186/s12934-024-02630-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12934-024-02630-8

Similar Items