Development and validation of a recombinant human TNF-α based ELISA to detect and quantify adalimumab

Development and validation of a recombinant human TNF-α based ELISA to detect and quantify adalimumab

Adalimumab, a humanized IgG1 monoclonal antibody is currently used to treat inflammatory diseases. However, a sensitive, in-house ELISA for evaluating inter- and intra-individual pharmacokinetic variability of adalimumab remains limited. In this study, an ELISA was developed to measure adalimumab le...

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Main Authors: Dinesh Kumar Saini, Manjunath S. Devaramani, Hemalakshmi Shanmugavel, Syeda Zuhin Tabassum, Kiran Kumar Mudnakudu-Nagaraju, Jalahalli Mariswamy Siddesha, Radhakrishna Shetty
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Adalimumab
Arthritis
Inflammation
ELISA
Pharmacokinetics
Bioanalysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000925
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