Detection of the GH analogue somatrogon in doping control urine samples by means of LC-HRMS/MS

Detection of the GH analogue somatrogon in doping control urine samples by means of LC-HRMS/MS

Abstract Somatrogon is a synthetic growth hormone (GH) analog, whose misuse in sports is prohibited at all times. As analytical approaches complementary to existing immunological GH detection methods were considered beneficial for its detection in doping control serum samples, a sensitive and specif...

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Main Authors: Katja Walpurgis, Andreas Thomas, Alexandra Rauer, Bettina Majer, Mitsuhiko Sato, Masato Okano, Maneera Al-Jaber, Wadha Abushareeda, Cristian-Gabriel Arsene, Hans Geyer, Mario Thevis
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Affinity purification
Doping
Growth hormone analogue
LC-HRMS/MS
Tryptic digestion
Ultrafiltration
Online Access:https://doi.org/10.1038/s41598-025-96361-4
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https://doi.org/10.1038/s41598-025-96361-4

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