Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes
A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We c...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6170154 |
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| author | Sandeep Dhindsa Rama Chemitiganti Husam Ghanim Evangelina Santiago Adnan Haider Natalia Chaar Mary Mok Alexis McKee Paresh Dandona |
| author_facet | Sandeep Dhindsa Rama Chemitiganti Husam Ghanim Evangelina Santiago Adnan Haider Natalia Chaar Mary Mok Alexis McKee Paresh Dandona |
| author_sort | Sandeep Dhindsa |
| collection | DOAJ |
| description | A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men). Insulin or saline was administered intranasally on two different occasions, at least one week apart. Blood samples were collected to measure LH concentrations every 15 minutes for 5 hours. Study drug was administered intranasally after a 2-hour baseline sampling period. Patients remained fasting throughout the procedure. The primary endpoint of the study was to compare the change in LH concentrations after intranasal insulin as compared to placebo (intranasal saline). Change was defined as the difference between baseline LH concentrations (average of the 9 samples collected in two hours prior to drug administration) and average LH concentrations following drug administration (average of the 12 samples collected in 3 hours). There was no change in LH concentrations following insulin administration as compared to placebo in men with diabetes or in lean men. We conclude that one dose of 40 IU of regular insulin administered intranasally does not change LH concentrations acutely in men. |
| format | Article |
| id | doaj-art-019e86019d4440da83fea94decc53cad |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-019e86019d4440da83fea94decc53cad2025-08-20T03:22:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/61701546170154Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with DiabetesSandeep Dhindsa0Rama Chemitiganti1Husam Ghanim2Evangelina Santiago3Adnan Haider4Natalia Chaar5Mary Mok6Alexis McKee7Paresh Dandona8Division of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo and Kaleida Health 462 Grider Street, Buffalo NY-14215, USADivision of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, Texas Tech University Health Sciences Center, 800 West 4th Street, Odessa, TX 79763, USADivision of Endocrinology, Diabetes and Metabolism, Saint Louis University, 1402 S Grand Blvd, St. Louis MO-63141, USADivision of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo and Kaleida Health 462 Grider Street, Buffalo NY-14215, USAA quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men). Insulin or saline was administered intranasally on two different occasions, at least one week apart. Blood samples were collected to measure LH concentrations every 15 minutes for 5 hours. Study drug was administered intranasally after a 2-hour baseline sampling period. Patients remained fasting throughout the procedure. The primary endpoint of the study was to compare the change in LH concentrations after intranasal insulin as compared to placebo (intranasal saline). Change was defined as the difference between baseline LH concentrations (average of the 9 samples collected in two hours prior to drug administration) and average LH concentrations following drug administration (average of the 12 samples collected in 3 hours). There was no change in LH concentrations following insulin administration as compared to placebo in men with diabetes or in lean men. We conclude that one dose of 40 IU of regular insulin administered intranasally does not change LH concentrations acutely in men.http://dx.doi.org/10.1155/2018/6170154 |
| spellingShingle | Sandeep Dhindsa Rama Chemitiganti Husam Ghanim Evangelina Santiago Adnan Haider Natalia Chaar Mary Mok Alexis McKee Paresh Dandona Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes International Journal of Endocrinology |
| title | Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes |
| title_full | Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes |
| title_fullStr | Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes |
| title_full_unstemmed | Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes |
| title_short | Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes |
| title_sort | intranasal insulin administration does not affect lh concentrations in men with diabetes |
| url | http://dx.doi.org/10.1155/2018/6170154 |
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