Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the intracellular deposition of Tau protein and extracellular deposition of amyloid-β peptide (Aβ). AD is also characterized by neuroinflammation and synapse loss, among others. The S100 family is a group of calcium-bi...

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Bibliographic Details
Main Authors: Joana Saavedra, Mariana Nascimento, António J. Figueira, Marina I. Oliveira da Silva, Tiago Gião, João Oliveira, Márcia A. Liz, Cláudio M. Gomes, Isabel Cardoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
Aβ oligomers
cytoskeleton dysfunction
synapse loss
S100B
molecular chaperones
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1636365/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1636365/full

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