Dietary fermentable polyols fuel gut inflammation through M1 macrophage polarization and gut microbiota

Summary: While fermentable oligo- and di-, mono-saccharides and polyols (FODMAPs) have been implicated in exacerbating inflammatory bowel disease (IBD) symptoms, the exact influence of FODMAPs on gut microbiota and inflammation is unclear. Here, we show that sorbitol, a polyol, exacerbates colitis i...

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Bibliographic Details
Main Authors: Kensuke Sato, Miwa Tomioka, Masahiro Akiyama, Yasuyuki Matsuda, Hideki Hara, Haruki Sasa, Yosuke Kurashima, Joe Inoue, Shinji Fukuda, Yun-Gi Kim
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011952
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