SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia

SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia

Abstract SUMOylation, the covalent attachment of the small ubiquitin-like modifier (SUMO) to target proteins, and its reversal, deSUMOylation by SUMO proteases like Sentrin-specific proteases (SENPs), are crucial for initiating cellular responses to hypoxia. However, their roles in subsequent adapta...

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Main Authors: Alice Zhao, Laura Maple, Juwei Jiang, Katie N. Myers, Callum G. Jones, Hannah Gagg, Connor McGarrity-Cottrell, Ola Rominiyi, Spencer J. Collis, Greg Wells, Marufur Rahman, Sarah J. Danson, Darren Robinson, Carl Smythe, Chun Guo
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07271-8
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https://doi.org/10.1038/s41419-024-07271-8

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