MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein

MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein

Numerous host factors function as intrinsic antiviral effectors to attenuate viral replication. MARCH8 is an E3 ubiquitin ligase that has been identified as a host restriction factor that inhibits the replication of various viruses. This study elucidated the mechanism by which MARCH8 restricts respi...

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Bibliographic Details
Main Authors: Takashi Okura, Tatsuki Takahashi, Taichi Kameya, Fuminori Mizukoshi, Yusuke Nakai, Masatoshi Kakizaki, Mayuko Nishi, Noriyuki Otsuki, Hirokazu Kimura, Kei Miyakawa, Kazuya Shirato, Wataru Kamitani, Akihide Ryo
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
respiratory syncytial virus
small hydrophobic protein
MARCH8
ubiquitination
apoptosis
Online Access:https://www.mdpi.com/1999-4915/16/12/1935
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https://www.mdpi.com/1999-4915/16/12/1935

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