Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration

Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration

BackgroundIn advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and the activation of the Wnt/β-catenin pathway have been suggested to contribute to low tumour immune cell infiltration. The transcription factor...

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Bibliographic Details
Main Authors: Tanja Maier, Laura-Sophie Landwehr, Alexandra Triebig, Stefan Kircher, Marc P. Schauer, Thomas Knösel, Silviu Sbiera, Paul Schwarzlmueller, Petra Zimmermann, Martin Reincke, Isabel Weigand, Martin Fassnacht, Matthias Kroiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
immunohistochemistry
LEF-1
hypercortisolism
prognosis
marker
immune cell infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1502117/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1502117/full

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