Emergence and dissemination of multidrug-resistant Klebsiella pneumoniae harboring the novel tmexCD-toprJ RND efflux pump operon

Emergence and dissemination of multidrug-resistant Klebsiella pneumoniae harboring the novel tmexCD-toprJ RND efflux pump operon

The global emergence of multidrug-resistant (MDR) Klebsiella pneumoniae, particularly carbapenem-resistant K. pneumoniae (CRKP), presents a severe public health threat, limiting available treatment options. Tigecycline and eravacycline, have been considered a last-resort therapeutic against MDR Ente...

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Bibliographic Details
Main Authors: Haojin Gao, Bingjie Wang, Meilan Li, Peiyao Zhou, Chunyang Wu, Cailing Wan, Li Shen, Jiana Fu, Weihua Han, Ying Zhou, Fangyou Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
carbapenem-resistant Klebsiella pneumoniae (CRKP)
tigecycline (TGC)
eravacycline
tmexCD-toprJ
hypermucoviscous
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1579880/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1579880/full

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