Intratracheal Aerosolization of <i>Nocardia farcinica</i> in Mice Optimizes Bacterial Distribution and Enhances Pathogenicity Compared to Intranasal Inoculation and Intratracheal Instillation

Intratracheal Aerosolization of <i>Nocardia farcinica</i> in Mice Optimizes Bacterial Distribution and Enhances Pathogenicity Compared to Intranasal Inoculation and Intratracheal Instillation

<i>Nocardia</i>, an easily missed but potentially fatal opportunistic pathogen, can lead to serious infections like lung and brain abscesses. Intranasal inoculation (IN) is the traditional approach for constructing a <i>Nocardia</i>-induced pneumonia mice model, while it usua...

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Bibliographic Details
Main Authors: Bingqian Du, Ziyu Song, Jirao Shen, Jiang Yao, Shuai Xu, Xiaotong Qiu, Min Yuan, Zhenjun Li
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
<i>Nocardia farcinica</i>
intratracheal aerosolization
mice pneumonia model
Online Access:https://www.mdpi.com/2218-273X/15/7/950
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