Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis

Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis

Abstract Background Recent studies emphasize the significance of copper dyshomeostasis in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, thereby highlighting the role of copper in neurotoxicity. Cuproptosis, a novel mechanism of copper-dependent cell death, remains underexplored, p...

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Main Authors: Yinuo Chen, Yiyang Nan, Lang Xu, Anqi Dai, Rosa Maria Martinez Orteg, Mantong Ma, Yan Zeng, Jinquan Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Particle and Fibre Toxicology
Online Access:https://doi.org/10.1186/s12989-025-00633-w
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https://doi.org/10.1186/s12989-025-00633-w

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