RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway

RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway

Abstract Docetaxel is a widely used first-line treatment for castration-resistant prostate cancer (CRPC). RhoB, a member of the Rho GTPase family, plays a major role in prostate cancer metastasis by modulating the PI3K-AKT signaling pathway. It is crucial in regulating cytoskeletal reassembly, cell...

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Bibliographic Details
Main Authors: Tiantian Sheng, Hang Su, Lu Yao, Zhen Qu, Hui Liu, Wenjuan Shao, Xiangyu Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Prostate cancer
RhoB
CRISPR/Cas9
RNA-Seq
Docetaxel
Online Access:https://doi.org/10.1186/s12885-025-13762-4
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https://doi.org/10.1186/s12885-025-13762-4

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