A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Abstract Background Gastrin-releasing peptide receptor (GRPR) is overexpressed in several cancers, including prostate and breast, making it an attractive target for radiopharmaceutical development. Studies on GRPR-targeting radioligands highlight the critical role of the spacer region between the GR...

Full description

Saved in:
Bibliographic Details
Main Authors: Esther Olaniran Håkansson, Ivan V. Zelepukin, Karim Obeid, Athanasios Bitzios, Ekaterina Bezverkhniaia, Amulya Sunkara, Ulrika Rosenström, Anna Orlova, Luke R. Odell, Panagiotis Kanellopoulos
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Research
Subjects:
Radiopharmaceuticals
GRPR
Bombesin analogue
Antagonist
Prostate cancer
Structure-properties relationship
Online Access:https://doi.org/10.1186/s13550-025-01301-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13550-025-01301-y

Similar Items