A Critical Analysis of the CFD-DEM Simulation of Pharmaceutical Aerosols Deposition in Upper Intra-Thoracic Airways: Considerations on Aerosol Transport and Deposition

A Critical Analysis of the CFD-DEM Simulation of Pharmaceutical Aerosols Deposition in Upper Intra-Thoracic Airways: Considerations on Aerosol Transport and Deposition

The reliability and accuracy of numerical models and computer simulations to study aerosol deposition in the human respiratory system is investigated for a patient-specific tracheobronchial tree geometry. A computational fluid dynamics (CFD) model coupled with discrete elements methods (DEM) is used...

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Bibliographic Details
Main Authors: Georgi H. Spasov, Riccardo Rossi, Andrea Vanossi, Ciro Cottini, Andrea Benassi
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceutics
Subjects:
orally inhaled drug products
pharmaceutical aerosol
aerosol deposition
CFD-DEM simulation
dry powder for inhalation
human lungs
Online Access:https://www.mdpi.com/1999-4923/16/9/1119
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https://www.mdpi.com/1999-4923/16/9/1119

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