Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice generated by the Wellcome Trust Sanger Institute Mous...

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Main Authors: J H Duncan Bassett, Apostolos Gogakos, Jacqueline K White, Holly Evans, Richard M Jacques, Anne H van der Spek, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Edward Ryder, David Sunter, Alan Boyde, Michael J Campbell, Peter I Croucher, Graham R Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002858&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002858&type=printable

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