Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging
Objective The preoperative (clinical and radiological) depth of invasion (DOI) in early tumours can guide the surgeons in deciding elective neck dissection, the extent of invasive surgery, the need for reconstruction, potential adjuvant treatment and the patient's prognosis. This study aimed to...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000360 |
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| author | Mahesh Sultania Priyansh Jain Itisha Chaudhary Hemanth Ghalige Simran Sidhu Sudipta Mohakud G. Sudhakar K. Raghuram Dillip Muduly Amit Adhya Sandip Barik Saroj Majumdar Madhabananda Kar |
| author_facet | Mahesh Sultania Priyansh Jain Itisha Chaudhary Hemanth Ghalige Simran Sidhu Sudipta Mohakud G. Sudhakar K. Raghuram Dillip Muduly Amit Adhya Sandip Barik Saroj Majumdar Madhabananda Kar |
| author_sort | Mahesh Sultania |
| collection | DOAJ |
| description | Objective The preoperative (clinical and radiological) depth of invasion (DOI) in early tumours can guide the surgeons in deciding elective neck dissection, the extent of invasive surgery, the need for reconstruction, potential adjuvant treatment and the patient's prognosis. This study aimed to validate the 8th AJCC clinical T stage using DOI, assess interobserver bias, and correlate the clinical, radiological and pathological T stages. Materials and methods: This was a prospective clinical study carried out from December 2019 to June 2023 at an academic tertiary care centre. Patients with squamous cell carcinoma of oral cavity and lip without involvement of skin or bone undergoing upfront surgery were included. The clinical assessment of T stage using DOI was done by three examiners, blinded to each other. The radiological T stage was assessed by an MRI and pathological T stage on fixed formalin surgical specimen. Results: A total of 173 patients were assessed during the study period, out of which 44 met the inclusion criteria. There was a fair agreement regarding the combined clinical T stage between all three examines. A statistically significant correlation was found between the clinical and pathological T stage (p-value 0.010), the radiological and pathological T stage (p-value 0.001) and clinical and radiological T stage (p-value 0.004). Conclusion: The clinical and radiological T stage using DOI correlated well with the pathological T stage. The 8th AJCC clinical T stage of oral squamous cell carcinoma was accurate in our study population. |
| format | Article |
| id | doaj-art-00773e0537dc4c3bb9cafd8ec1dd1f90 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-00773e0537dc4c3bb9cafd8ec1dd1f902025-01-09T06:15:17ZengElsevierOral Oncology Reports2772-90602024-03-019100190Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imagingMahesh Sultania0Priyansh Jain1Itisha Chaudhary2Hemanth Ghalige3Simran Sidhu4Sudipta Mohakud5G. Sudhakar6K. Raghuram7Dillip Muduly8Amit Adhya9Sandip Barik10Saroj Majumdar11Madhabananda Kar12Department of Head and Neck Oncology, Bagchi Sri Shankara Cancer Centre and Research Institute, Bhubaneswar, India; Corresponding author.Department of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Radiodiagnosis, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Radiodiagnosis, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Pathology and Laboratory Medicine, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Radiation Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Radiation Oncology, AIIMS, Bhubaneswar, Odisha, IndiaDepartment of Surgical Oncology, AIIMS, Bhubaneswar, Odisha, IndiaObjective The preoperative (clinical and radiological) depth of invasion (DOI) in early tumours can guide the surgeons in deciding elective neck dissection, the extent of invasive surgery, the need for reconstruction, potential adjuvant treatment and the patient's prognosis. This study aimed to validate the 8th AJCC clinical T stage using DOI, assess interobserver bias, and correlate the clinical, radiological and pathological T stages. Materials and methods: This was a prospective clinical study carried out from December 2019 to June 2023 at an academic tertiary care centre. Patients with squamous cell carcinoma of oral cavity and lip without involvement of skin or bone undergoing upfront surgery were included. The clinical assessment of T stage using DOI was done by three examiners, blinded to each other. The radiological T stage was assessed by an MRI and pathological T stage on fixed formalin surgical specimen. Results: A total of 173 patients were assessed during the study period, out of which 44 met the inclusion criteria. There was a fair agreement regarding the combined clinical T stage between all three examines. A statistically significant correlation was found between the clinical and pathological T stage (p-value 0.010), the radiological and pathological T stage (p-value 0.001) and clinical and radiological T stage (p-value 0.004). Conclusion: The clinical and radiological T stage using DOI correlated well with the pathological T stage. The 8th AJCC clinical T stage of oral squamous cell carcinoma was accurate in our study population.http://www.sciencedirect.com/science/article/pii/S2772906024000360Oral cancerDepth of invasion8th AJCC TNMClinical assessmentRadiological assessmentPathological stage |
| spellingShingle | Mahesh Sultania Priyansh Jain Itisha Chaudhary Hemanth Ghalige Simran Sidhu Sudipta Mohakud G. Sudhakar K. Raghuram Dillip Muduly Amit Adhya Sandip Barik Saroj Majumdar Madhabananda Kar Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging Oral Oncology Reports Oral cancer Depth of invasion 8th AJCC TNM Clinical assessment Radiological assessment Pathological stage |
| title | Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| title_full | Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| title_fullStr | Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| title_full_unstemmed | Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| title_short | Validation of clinical T stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| title_sort | validation of clinical t stage using depth of invasion in the patients with oral squamous cell carcinoma and its correlation with imaging |
| topic | Oral cancer Depth of invasion 8th AJCC TNM Clinical assessment Radiological assessment Pathological stage |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000360 |
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