Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction

Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction

A series of 1,5-disubstituted tetrazole-indole hybrids were synthesized via a high-order multicomponent reaction consisting of an Ugi-azide/Pd/Cu-catalyzed hetero-annulation cascade sequence. This operationally simple one-pot protocol allowed high bond-forming efficiency and creating six new bonds (...

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Main Authors: Cesia M. Aguilar-Morales, América A. Frías-López, Nadia V. Emilio-Velázquez, Alejandro Islas-Jácome, Angelica Judith Granados-López, Jorge Gustavo Araujo-Huitrado, Yamilé López-Hernández, Hiram Hernández-López, Luis Chacón-García, Jesús Adrián López, Carlos J. Cortés-García
Format: Article
Language:English
Published: Beilstein-Institut 2024-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
1,5-disubstituted tetrazoles
high-order multicomponent reaction
isocyanides
mcf-7 cell line
methanesulfonylindoles
ugi-azide reaction
Online Access:https://doi.org/10.3762/bjoc.20.256
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https://doi.org/10.3762/bjoc.20.256

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