Combining Intramuscular and Intranasal Immunization With the MF59‐Adjuvanted Respiratory Syncytial Virus Pre‐Fusion Protein Subunit Vaccine Induces Potent Humoral and Cellular Immune Responses in Mice

Combining Intramuscular and Intranasal Immunization With the MF59‐Adjuvanted Respiratory Syncytial Virus Pre‐Fusion Protein Subunit Vaccine Induces Potent Humoral and Cellular Immune Responses in Mice

ABSTRACT Respiratory syncytial virus (RSV) ranks as the second leading cause of infant death globally and a significant contributor to morbidity and mortality among adults over 60 years old. The development of effective RSV vaccines and immunoprophylaxis remains a key focus. In our research, we form...

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Main Authors: Jie Shi, Hong Lei, Yu Zhang, Chunjun Ye, Xiya Huang, Yishan Lu, Yanyan Liu, Jian Liu, Danyi Ao, Yingqiong Zhou, Jiong Li, Guangwen Lu, Xiangrong Song, Xiawei Wei
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
intranasal immunization
MF59 adjuvant
mucosal immunity
respiratory syncytial virus (RSV)
RSV pre‐fusion (preF) protein
Online Access:https://doi.org/10.1002/mco2.70301
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https://doi.org/10.1002/mco2.70301

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