Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study

Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study

Etoricoxib (ETC), a selective cyclooxygenase enzyme (COX-2) inhibitor, is widely utilized to manage pain and inflammation. Nevertheless, its therapeutic efficacy is limited by poor aqueous solubility, low bioavailability, and significant cardiovascular risks, including increased blood pressure, thro...

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Bibliographic Details
Main Authors: Bakul Akter, Silvia Aishee, Abdullah Hridoy, Md. Mehedi Hasan Pulok, Mohammad Ariful Islam, Antu Biswas, Aurna Patwary, Majedul Hoque, MD. Sazidul Islam, Md. Nipatul Hasan Nirob, Faisal Islam Chowdhury, Monir Uzzaman
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Chemical Physics Impact
Subjects:
Etoricoxib
Physicochemical
Molecular Dynamics simulation
Molecular docking
ADMET
PASS
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022425000180
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