Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

Summary: HIV-1 broadly neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutraliza...

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Bibliographic Details
Main Authors: Kim-Marie A. Dam, Harry B. Gristick, Yancheng E. Li, Zhi Yang, Priyanthi N.P. Gnanapragasam, Anthony P. West, Jr., Michael S. Seaman, Pamela J. Bjorkman
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500484X
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