The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

Background: Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides an opportunity to comprehensively unravel the contributory role of monocytes...

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Bibliographic Details
Main Authors: Yimei Ding, Xue Luan, Jiaqi Hou
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Primary Sjögren's syndrome
Monocytes and macrophages
Mendelian randomization
Single-cell sequencing
Pathogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024151614
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