Targeted treatment and survival in advanced non-squamous non-small cell lung cancer patients – a nationwide and longitudinal study by Johanne Elise Nyen, Anja Ødegård Booth, Øyvind Husby, Christoffer Bugge, Ingrid Engebretsen, Francisco Oteiza, Åslaug Helland, Åslaug Helland, Lars Fjellbirkeland, Lars Fjellbirkeland, Odd Terje Brustugun, Odd Terje Brustugun, Bjørn Henning Grønberg, Bjørn Henning Grønberg

“…ObjectivesWe aimed to describe treatment patterns, time on treatment (ToT) and overall survival (OS) for patients with advanced non-squamous, EGFR+, ALK+ and ROS1+ NSCLC in Norway.Materials and methodsWe extracted data on patients ≥ 18 years diagnosed with advanced non-squamous NSCLC between 2015 and 2022 from the Cancer Registry of Norway and data on cancer drug therapy from the Norwegian Patient Registry and the Norwegian Prescribed Drug Registry. …”
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Association between lipid profiles and platelet indices in middle-aged and older Chinese: a population-based cross-sectional study by Yanbo Li, Li Qin, Xiaoyong Li, Yixin Niu, Lina Chen, Xinyan Zhang, Hui Ran, Zhen Yang, Qing Su, Hongmei Zhang

“…RCS analyses demonstrated nonlinear dose-response patterns between TG and PLT/MPV/PDW. HDL exhibited a significant positive correlation with MPV, specifically observed in the female subgroup. …”
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The effects of masseter muscle morphology on three-dimensional occlusion and temporomandibular joint in adult patients with skeletal class II malocclusion: a CBCT study by Yiyang Shen, Xin Li, Xiaoyan Feng, Chenxing Zhang, Yufeng Shang, Jun Lin

“…Methods A total of 87 adult participants (mean ± standard deviation age = 25.98 ± 4.58 years) were included in the study and categorized into four groups: skeletal Class I, skeletal Class II high-angle, average-angle, and low-angle. …”
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Evaluation of a national supermarket intervention supporting vulnerable families in healthy meal practices: a natural experiment by Marjolijn Vos, Viktor L. J. Proesmans, Anneleen Van Kerckhove, Benedicte Deforche, Nathalie Michels, Maartje P. Poelman, Wendy Van Lippevelde

“…Methods Food purchase data (total number of product purchases, n = 260,214) from participating families with lower SES (n = 134) were analyzed over a period of four and a half years, using a longitudinal within-group pre-post design. …”
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Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 by Tianye Li, Haoxiang Zhang, Mengyi Lian, Qionghua He, Mingwei Lv, Lingyun Zhai, Jianwei Zhou, Kongming Wu, Ming Yi

“…This study aimed to analyze the global epidemiological trends of these cancers from 1990 to 2021, offering insights into their evolving patterns and providing valuable information for health policymakers to allocate healthcare resources more effectively. …”
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A SITC vision: adapting clinical trials to accelerate drug development in cancer immunotherapy by Pedro J Romero, Leisha A Emens, Elizabeth Garrett-Mayer, Valsamo Anagnostou, Jason J Luke, Ann W Silk, Thomas U Marron, Jane Perlmutter, Brianna Hoffner, Connie Szczepanek

“…Progression criteria have been redefined due to the unique response patterns of IO. Harnessing the power of both biomarkers and the neoadjuvant setting earlier in drug development is of broad interest. …”
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Forecasting habitat suitability of tropical karst plants in a warmer world — Thailand’s Begonia diversity as a key example by Sirilak Radbouchoom, Sirilak Radbouchoom, Marjorie D. delos Angeles, Marjorie D. delos Angeles, Marjorie D. delos Angeles, Boniface K. Ngarega, Thamarat Phutthai, Harald Schneider

“…Together, these elements significantly shape the distribution patterns of Begonia diversity in these unique habitats. …”
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Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…Prognosis is poor and survival is low in patients diagnosed with this disease, with a survival rate of ~12% at 5 years. Immunotherapy, including adoptive T cell transfer therapy, has not impacted the outcomes in patients with PDAC, due in part to the hostile tumor microenvironment (TME) which limits T cell trafficking and persistence. …”
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Hypothetical Behavioral Interventions for Mitigating the Cardiovascular Effects of Long‐Term Fine Particulate Matter Exposure: Analyses From 2 Prospective Cohorts by Jialong Wu, Liang Wang, Xu Han, Linya Huang, Qiong Meng, Tingting Yang, Quzong Deji, Zihao Wang, Bing Guo, Xing Zhao

“…METHODS AND RESULTS The parametric g‐formula was used to quantify the potential reduction in PM2.5 effect on CVD under different scenarios of hypothetical behavioral interventions (including dietary patterns, physical activity, body mass index, alcohol consumption, smoking, and dietary supplements). …”
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Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers by Yuan Zhong, Siqi Huang, Meixia Zou, Yiming Chen, Peifeng Shen, Yanan He, Yuanchao Li, Chunlong Liu, Zhibiao Chen

“…Burst detection and timeline analyses of keywords and references were conducted to identify emerging trends and temporal patterns.ResultsA total of 1,223 articles were identified. …”
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Environmental monitoring and spatiotemporal trend analysis of avian influenza virus in Xinjiang, 2021-2023 by Zhe Yin, Fuerhati Wushouer, Jia Huang, Yan Dong, Qi Wang, Xiapikatijiang Aihaiti, Xiayidanmu Abudusaimaiti, Yuanyuan Ma, Zihan Chen, Ruiying Qiu, Quanxi Li, Zhenguo Gao

“…Significant differences in detection rates were observed across different years, regions, sample types, and monitoring sites. …”
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Evaluation of the MyFertiCoach Lifestyle App for Subfertile Couples: Single-Center Evaluation of Augmented Standard Care by Jesper Smeenk, Ellen Smit, Marc Jacobs, Ilse van Rooij

“…We used (hierarchical) linear mixed models (LMMs) to estimate changes in outcomes. For missing data patterns deemed missing not at random, joint modeling was applied. …”
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Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches by Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu

“…Conclusion DII, a marker of pro-inflammatory dietary patterns, was significantly linked to CKM syndrome progression and mortality, partly by influencing biological aging. …”
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Assessment of factors influencing the citation level of scientific publications in the field of sport and physical activity by Sergii Iermakov, Georgiy Korobeynikov

“…The analysis of bibliographic data revealed the following patterns. The citation level of publications is associated with the number of cited references (NR); however, the correlation remains weak (Spearman's coefficients: 0.1329 for TC and 0.1342 for Z9). …”
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Association of hyperuricemia with higher miscarriage rates and lower live birth rates in women undergoing IVF/ICSI by Ling Zhou, Jiahuan Luo, Shuhua Zhao, Longda Wang, Meng Rao, Huawei Wang, Li Tang

“…Notably, the detrimental effects of HUA exhibited modality-specific patterns, with frozen-thawed embryo transfer (FET) cycles demonstrating greater vulnerability to HUA than fresh transfers. …”
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Transgressive hybrids as hopeful holobionts by Benjamin Thomas Camper, Andrew Stephen Kanes, Zachary Tyler Laughlin, Riley Tate Manuel, Sharon Anne Bewick

“…This is the pitfall that Dobzhansky fell into over 80 years ago when he used hybrid sterility and inviability to conclude that hybridization hinders evolution. …”
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Coeliac disease on the rise: the COVID-19 vaccination hypothesis by Maisam Akroush, Aktham Akroush, Zain Al Qaisi, Noura Mheidat

“…Its broad clinical spectrum necessitates careful suspicion for timely diagnosis. Over the past 2 years, we have observed a sharp rise in cases, coinciding with the post-pandemic era,1 prompting this study. …”
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Understanding the nature and dynamics of self-affirmation in non-depressed and subclinically depressed Indian adults: a thematic analysis by Gyanesh Kumar Tiwari, Priyanka Parihar, Ajit Kumar Singh, Amit Kumar Macorya, Anurag Shukla, Archana Singh, Archna Choudhary, Ashutosh Pandey

“…Methods Using a qualitative research design, forty-three individuals aged 20–30 years (18 healthy, 25 subclinically depressed individuals) were selected based on depression measurement. …”
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Cystic Echinococcosis: Knowledge, Attitude, and Practices (KAP) among Surgically Operated Cases in Fars Province, Southern Iran by Zahra Hosseini, Reza Shahriarirad, Bahador Sarkari

“…A total of 180 CE patients with a mean age of 35.64 (±17.59) years were recruited. The mean score of participant’s knowledge was 8.7 (SD=2.8, range: 0-17), whereas these scores were 1.3 (SD=0.7, range 0-2) for attitude and 1.2 (SD=1.0, range 0-4) for practice. …”
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Study on the age-period-cohort effects of cognitive abilities among older Chinese adults based on the cognitive reserve hypothesis by Qian Yang, Tong Yu

“…These findings collectively contribute to our understanding of cognitive aging patterns and their underlying mechanisms among older Chinese adults.…”
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