CLINICAL CASE OF REPLACEMENT OF ENDOTHELIN RECEPTOR ANTAGONIST (BOSENTAN) BY SOLUBLE GUANYLATE CYCLASE STIMULATOR (RIOCIGUAT) IN THE PATIENT WITH PULMONARY ARTERIAL HYPERTENSION by E. A. Devetyarova, A. A. Dyuzhikov, A. A. Dyuzhikova, S. V. Sobin, A. V. Sumin, E. V. Pashchenko

“…At the present similar approach (switching) has already been tested, for example, in switching from one endothelin receptor antagonist (ERA) to another, or from phosphodiesterase type 5 inhibitor (iPDE-5) to soluble guanylate cyclase stimulator (sGC). …”
Get full text

Effects and predictors of intravenous lidocaine infusion for patients with fibromyalgia. by Min Liu, Stephany Harris, Anna P Andreou, Adnan Al-Kaisy, David Pang, Xuenong Bo

“…Adult patients who had completed questionnaires and quantitative sensory testing (QST) before IV lidocaine infusion were included. …”
Get full text

Methods of Calculating the Indexes of Intellectual Capital of Organizations by V. A. Korzhak

“…Competitive functioning at the micro and macro levels of businesses in different industries creates the need to make changes in the assessment of the impact on the performance of companies of tangible and intangible assets, leading to an increase in the value of both products and companies. …”
Get full text

Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor g... by Dipti Thakkar, Lillian Liu, Bhushan Dharmadhikari, Shalini Paliwal, Siyu Guan, Shreya Kar, Nikhil K Tulsian, Joshua J Gruber, Leah DiMascio, Konrad H Paszkiewicz, Piers J Ingram, Jerome D Boyd-Kirkup

“…Background Despite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. …”
Get full text

Defining the relationship between clinician-rated ECOG performance status and patient-reported health-related quality of life scores in men with metastatic hormone-naïve prostate c... by Ikenna I. Nnabugwu, Eric N. Obikeze, Chinwe A. Nnabugwu, Solomon K. Anyimba, Okwudili C. Amu, Okezie M. Mbadiwe, Kevin S. N. Echetabu, Ijeoma L. Okoronkwo

“…Results Of the 224 participants (mean age: 70.62 ± 7.34), about 60.7% had ≥ 12years of formal education and 84.9% had ISUP grade ≥ 3 cancer. …”
Get full text

Comparative Evaluation of Intra-articular Ozone and Steroid Treatments in Patients with Coxarthrosis under Ultrasound Guidance: A Retrospective Study by Yilmaz Karaduman, Arzu Muz, Azize Serçe, Servi Yildirim, Ismail Eren Durmus, Suna Akin Takmaz

“…Statistical analysis were conducted using Unpaired t-tests and Chi-square tests. A p-value <0.05 was considered statistically significant. …”
Get full text

Evaluation of the Relationship between the Pulp and Periapical Lesions with Controlled Type Type 2 Diabetes in Patients Referred to the Dental Clinic: A Radiographic Evaluation by Abbas Mesgarani, Alireza Sedighi, Ozra Akha, Abolfazl Hosseinnataj, Ali Golmohammadi, Maede Salehi

“…For inferential analysis, chi-square tests and independent t-tests were used. Results: Among the 90 participants, 53 were women and 37 were men. …”
Get full text

Galectin-3: role in the formation of various hemodynamic phenotypes of heart failure and interaction with some neurohumoral factors by A. K. Kurbonov, A. G. Gadaev, N. M. Nurillaeva, M. M. Ernazarov, D. O. Nasretdenova

“…A total of 210 male and female patients with HF were examined (mean age 64,1±1,4 years). HF was established on the basis of patient complaints, medical history, physical examination and laboratory tests using the 2016 ESC Chronic Heart Failure Guidelines. …”
Get full text

Human Tapeworm from Simalungun, Indonesia by Umar Zein, Sahat Siregar, Hadiki Habib, Indra Janis, Abdul H Pane, Teguh W Sardjono

“…A 46-years-old man from Indonesia, resides in Nagori Dolok Village, Silau Kahaean Subdistrict, Simalungun District, Sumatra Utara Province, had of spontaneous discharge of tapeworm segments (proglottids) from anus almost every day for ten years. …”
Get full text

Human Tapeworm from Simalungun, Indonesia by Umar Zein, Sahat Siregar, Hadiki Habib, Indra Janis, Abdul H Pane, Teguh W Sardjono

“…A 46-years-old man from Indonesia, resides in Nagori Dolok Village, Silau Kahaean Subdistrict, Simalungun District, Sumatra Utara Province, had of spontaneous discharge of tapeworm segments (proglottids) from anus almost every day for ten years. …”
Get full text

Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study by Peter M Smith, Hind Sbihi, Wei Zhang, Adeera Levin, Naveed Z Janjua, Hiten Naik, Bingyue Zhu, Lee Er, Karen Tran

“…Participants comprised adults who tested positive for SARS-CoV-2 by PCR at least 2 years before questionnaire completion and were working age (18–64) at the time of infection. …”
Get full text

Experiences of Home‐Based Pulmonary Rehabilitation With mHealth and Centre‐Based Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: A Qualitative Study... by Hannah Rutherford, Marita Dale, Sally Wootton, Rashmi Pithavadian, Sarah Dennis, Sarah Brown, Jennifer A. Alison, Andrew S. L. Chan, Ian A. Yang, Zoe McKeough

“…Patient or Public Contribution Consumers co‐designed and user‐tested the m‐PR app. The qualitative data presented in this manuscript was obtained through interviews with consumers.…”
Get full text

Brain-behavior correlates of rhythmic timing and auditory-motor synchronization in children with developmental coordination disorder: an EEG study by Marija Pranjić, Marija Pranjić, Jason Leung, Ka Lun Tam, Helene Polatajko, Timothy Welsh, Tom Chau, Tom Chau, Michael Thaut, Michael Thaut

“…Thirty-four children aged 7–11 years participated, including children with DCD and typically developing children with and without musical training. …”
Get full text

No significant differences in postoperative clinical outcomes evolution after fresh osteochondral allograft transplantation of the knee between patients with pathological and non‐p... by Pablo Eduardo Gelber, Eduard Ramírez‐Bermejo, Anna Castellà‐Pujol, Aránzazu Gonzalez‐Osuna, Oscar Fariñas

“…The hypothesis was that patients with preoperative pathological scores on psychological factors would show worsen functional outcomes after FOCA transplantation of the knee. …”
Get full text

Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity by Jungeun Lee, Ho Jin Lee, Yeongcheol Lee, Bumhee Lim, Jongsik Gam, Dong-Chan Oh, Jeeyeon Lee

“…Despite extensive efforts over 40 years, few effective KRAS inhibitors have been developed to date, mainly due to the undruggable features of KRAS proteins. …”
Get full text

CO2 utilization and sequestration potential in deep coal seams: A case study on Carboniferous coals from the Karaganda Basin, Kazakhstan by Majid Safaei-Farouji, David Misch, Reinhard F. Sachsenhofer, Nikolaos Kostoglou, Garri Gaus, Thorsten Bauersachs, Medet Junussov, Milovan Fustic

“…This is probably due to interactions between CO2 and functional groups leading to enhanced physisorption at LP and chemisorption and matrix swelling at HP conditions. …”
Get full text

Genotyping of ABCC8, KCNJ11, and HADH in Iranian Infants with Congenital Hyperinsulinism by Somayyeh Hashemian, Reza Jafarzadeh Esfehani, Siroos Karimdadi, Nosrat Ghaemi, Peyman Eshraghi, Najmeh Malekzadeh Gonabadi, Amirhossein Sahebkar, Rahim Vakili, Mohammad Reza Abbaszadegan

“…The present case series took place in Mashhad, Iran, within 11 years. Every child who had a clinical phenotype and confirmatory biochemical tests of CHI enrolled in this study. …”
Get full text

Association between foot morphology and dynamic knee valgus during single leg squats in recreational male football players: a cross-sectional study by Vinosh Kumar Purushothaman, Noorul Uyoon Ahmed Ibrahim Didi, Ambusam Subramaniam, Arun Vijay Subbarayalu, Sivasankar Prabaharan, Mariam Ameer, Ajmal Sheriff, Arun Prathap, Palanivel Rubavathi Marimuthu

“…Male football players ( n = 151) aged between 18 and 30 years belonging to three Malaysian football clubs were recruited. …”
Get full text

Effect of communicating genetic risk of type 2 diabetes and wearable technologies on wearable device-measured behavioural outcomes in East Asians: protocol of a randomised controll... by Youngwon Kim, Shan Lou, Brian Chung, Simon Griffin, Ziyuan Chen, Job G Godino, Flora Lai Tung Cheung, Michael Multhaup, Derwin King Chung K C Chan, Harrison Hin Sheung Ho, Tsz Him Timothy Tse, Shiu Lun Ryan Au Yeung, Joni H Zhang, Mengyao Wang

“…We aim to assess the effects of communicating genetic risk for T2D alone or in combination with wearable device functions on wearable device-measured PA among overweight or obese East Asians.Methods and analysis In a parallel group, randomised controlled trial, 355 overweight or obese East Asian individuals aged 40–60 years are allocated into one of three groups: one control and two intervention groups. …”
Get full text

Transcutaneous permeation enhancer complex for polymer-based transdermal patches by E. G. Kuznetsova, L. A. Salomatina, O. M. Kuryleva, Yu. B. Basok, V. I. Sevastianov

“…The irritant effect of the lidocaine-loaded transdermal polymeric matrix was tested on sexually mature young male New Zealand White rabbits. …”
Get full text