Muscle Fat and Volume Differences in People With Hip‐Related Pain Compared With Controls: A Machine Learning Approach by Chris Stewart, Evert O. Wesselink, Zuzana Perraton, Kenneth A. Weber II, Matthew G. King, Joanne L. Kemp, Benjamin F. Mentiplay, Kay M. Crossley, James M. Elliott, Joshua J. Heerey, Mark J. Scholes, Peter R. Lawrenson, Chris Calabrese, Adam I. Semciw

“…Methods This cross‐sectional study included sub‐elite/amateur football players (Australian football and soccer) with a greater than 6‐month history of HRP [n = 180, average age 28.32, (standard deviation 5.88) years, 19% female] and a control group of sub‐elite/amateur football players without pain [n = 48, 28.89 (6.22) years, 29% female]. …”
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Some growth factors in neoplastic tissues of brain tumors of different histological structure by O. I. Kit, E. M. Frantsiyants, E. E. Rostorguev, I. V. Balyazin-Parfenov, N. D. Cheryarina, L. S. Kozlova, Yu. A. Pogorelova

“…Age of patients ranged from 35 to 72 years. The level of growth factor was detected in the samples of tumor tissue and regions immediately adjacent to the tumor foci (peritumoral area) by the method of immunoassay and using standard test systems. …”
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FI-Lab predicts all-cause mortality, but not successful rehabilitation, among patients aged 65 and older after hip or pelvic fracture by Evgeniya Zikrin, Evgeniya Zikrin, Abdu El Karim Hilali, Abdu El Karim Hilali, David Shacham, David Shacham, Reut Frenkel, Reut Frenkel, Olga Abel, Olga Abel, Muhammad Abo Abed, Muhammad Abo Abed, Ahmed Abu-Ajaj, Ahmed Abu-Ajaj, Natalia Velikiy, Natalia Velikiy, Tamar Freud, Tamar Freud, Tamar Freud, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press

“…PurposeOver the past decade, the Frailty Index based on Laboratory data (FI-Lab index) has been effective in predicting complications during hospitalization, length of hospital stay, changes in functional status, and even mortality. The aims of the present study were to examine the associations between FI-Lab, rehabilitation outcomes, and mortality following hip and pelvic fractures.MethodsA retrospective study of patients 65 years of age and above who underwent rehabilitation after hip or pelvic fracture in the Geriatric Department, between January 2018 and December 2024. …”
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A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours by Yasutoshi Kuboki, Hendrik-Tobias Arkenau, Vivek Subbiah, Timothy Price, Gerald Falchook, Hans Prenen, Rafal Dziadziuszko, Hansen Wong, Iwona Lugowska, Daniel Tan, Weibing Shi, Ryota Shibaki, Min Hee Hong, Sant P Chawla, Jose G Monzon, Mun Hui, Caio Max Rocha Lima, Kejia Wang, Antreas Hindoyan, Mira Kistler

“…The inclusion criteria included a life expectancy of >3 months, ≥1 measurable or evaluable lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) V.1.1, an Eastern Cooperative Oncology Group performance status of ≤2 and adequate haematological, renal and hepatic function. Patients with prior treatment with checkpoint inhibitors, primary brain tumour or untreated or symptomatic brain metastases and leptomeningeal disease and history of other malignancy within the past 2 years were excluded.Interventions The planned doses were 240 mg, 480 mg and 1050 mg of AMG 404 administered every 4 weeks (Q4W).Primary and secondary outcome measures Primary endpoints were dose-limiting toxicities (DLTs), treatment-emergent adverse events, treatment-related adverse events, changes in vital signs and clinical laboratory tests. …”
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Implementation and effectiveness of a nurse-enabled, shared-care follow-up model for early breast cancer survivors (The IBIS-Survivorship Study): protocol for a stepped-wedge clust... by Karla Hemming, Jane Turner, Meinir Krishnasamy, Nicolas H Hart, Patsy Yates, Helen Skerman, Elizabeth Eakin, Jon Emery, Jane Mahony, Kerry Patford, Bogda Koczwara, Fiona Crawford-Williams, Caroline Kristunas, Raymond J Chan, G Bruce Mann, Mary Azer, Louisa G Collins, Jasotha Sanmugarajah, Bethany Crowe, Gillian Blanchard, Laura Healey, Rhea Liang, Paul Craft, Amy Shorthouse, Ruth McCaffery

“…Survivors often experience physical and psychological effects arising from breast cancer and its treatment, which can last months and years, adversely impacting quality of life. As the number of early breast cancer survivors increases, models of specialist-led follow-up care in hospital settings are not sustainable and evidence suggests that they may not meet survivors’ needs. …”
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Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Conclusions The behaviour change technique-based interventions are effective, targeting intention to engage in physical activity, in improving daily physical activity and functional outcomes in the short term, although evidence is limited for maintenance. …”
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Vitamin D receptor genetic variations in association to the susceptibility to prostate cancer: a case-control study in a Moroccan population by Kawtar Nabil, Abdelilah Laraqui, Ikram Tiabi, Kaoutar Anouar Tadlaoui, Mohammed Mrabti, Ahmed Ameur, Khalid Ennibi, Mustapha Benhessou, Moulay Mustapha Ennaji

“…Aim: It has been shown that the vitamin D receptor (VDR) gene and its biological functions can be affected by genetic alterations in the VDR gene. …”
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Multidimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition by Ming-Qiang Wang, Shi-Kun Guo, Peng-Fei Guo, Juan-Juan Yang, Guo-Ai Chen, Douglas Chesters, Michael C Orr, Ze-Qing Niu, Michael Staab, Jing-Ting Chen, Yi Li, Qing-Song Zhou, Felix Fornoff, Xiaoyu Shi, Shan Li, Massimo Martini, Alexandra-Maria Klein, Andreas Schuldt, Xiaojuan Liu, Keping Ma, Helge Bruelheide, Arong Luo, Chao-Dong Zhu

“…We tested for effects of tree species richness, tree phylogenetic, and functional diversity, and species and phylogenetic composition on species and phylogenetic diversity of both host and parasitoid communities and the composition of their interaction networks. …”
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TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): prot... by Charlotte Anderson, Nick Reed, Andrée-Anne Ledoux, Roger Zemek, Keith Yeates, Carolyn Emery, Pamela Fuselli, Isabelle J Gagnon, Kathryn J Schneider, Sharon Johnston, David R Howell, Richard Webster, Peter Tanuseputro, Andrew R Mayer, Miriam H Beauchamp, Rebecca Robillard, Christina L Master, Kristine Dalton, Khaled El Emam, John Leddy, Noah Silverberg, Jennifer Dawson, Martin H Osmond, Stephanie Cowle, Christopher Giza, Monica Lamoureux, Nicholas Barrowman, Kitty Chen, Daniel J Corwin, Erin Fox, Lisa M Albrecht, Araba Chintoh, Achelle Cortel-LeBlanc, Miguel Cortel-LeBlanc, Andrew Dodd, Steven Hicks, Stephen Alexander Kutcher, Carlos Lalonde, Rebekah C Mannix, Ivan Terekhov, Cheryl Lea Wellington

“…Seeking guidance from our Community Advisory Committee will ensure meaningful patient partnership and research findings that are relevant to the wider concussion community.Methods and analysis This prospective observational cohort study will recruit 5500 participants over 5 years from three 360 Concussion Care clinic locations across Ontario, Canada, with a subset of participants enrolling in specific objective assessments including testing of autonomic function, exercise tolerance, vision, advanced neuroimaging and fluid biomarkers. …”
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Comparative efficacy studies of nine Chinese traditional patent medicines for the treatment of post-myocardial infarction heart failure: A Bayesian network by Fuyun Jia, Shengwei Gao, Qiaochu Zhu, Opoku Bonsu Francis, Rui Liu, Yadong Wang, Rui Zhang, Shichuan Chen, Zilian Zhan, Xi Zhang, Qiang Xu

“…Introduction: Heart failure (HF) is a rapidly growing public health issue with an estimated prevalence of 64 million people globally. After many years of use and development, Traditional Chinese Medicine (TCM) has accumulated rich clinical usefulness in many diseases. …”
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Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease by Marianna Riello, Monica Moroni, Stefano Bovo, Flavio Ragni, Manuela Buganza, Raffaella Di Giacopo, Marco Chierici, Lorenzo Gios, Matteo Pardini, Matteo Pardini, Federico Massa, Federico Massa, Monica Dallabona, Elisa Vanzetta, Cristina Campi, Cristina Campi, Michele Piana, Michele Piana, Sara Garbarino, Manuela Marenco, Venet Osmani, Giuseppe Jurman, Antonio Uccelli, Antonio Uccelli, Bruno Giometto, Bruno Giometto, NeuroArtP3 Network, Filippo Gerli, Guido Pasquini, Claudia Niccolai, Matteo Betti, Emilio Portaccio, Maria Pia Amato, Rossi Andrea, Parodi Costanza, Ramaglia Antonia, Tortora Domenico, Severino Mariasavina, Andrea Falini, Antonella Castellano, Nicolò Pecco, Paola Scifo, Sonia Calloni

“…Also, our study used the results of single cognitive tests as a measure of specific cognitive functions allowing for a finer-grained analysis of risk factors with respect to the other studies that have principally used aggregated scores obtained by short neuropsychological batteries. …”
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Predicting Endpoint Temperature of Molten Steel in VD Furnace Refining Process Using Metallurgical Mechanism and Bayesian Optimization XGBoost by Ji XU, Zicheng XIN, Mo LAN, Wenhui LIN, Bo ZHANG, Qing LIU

“…Unlike other furnaces, the VD furnace lacks a heating function, leading to a significant drop in the temperature of molten steel during the refining process. …”
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Correlation between fatigue and pulmonary involvement in the post-COVID-19 condition: a cross-sectional study 6–12 months after hospital discharge by Paulo A Lotufo, Juliana C Ferreira, Eloisa Bonfa, Anna S Levin, Rodrigo Caruso Chate, Marta Imamura, Esper G Kallas, Roger Chammas, Thais Mauad, Izabel Marcilio, Nelson Gouveia, Ricardo Nitrini, José Eduardo Krieger, Marcio Valente Yamada Sawamura, Carlos Roberto Ribeiro de Carvalho, Cristiano Gomes, Jorge Hallak, Luis Yu, Marcio Mancini, Maria Elizabeth Rossi, Thiago Avelino-Silva, Edivaldo M Utiyama, Aluisio C Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C Montal, Leila Harima, Solange R G Fusco, Marjorie F Silva, Marcelo C Rocha, Carolina Carmo, Clarice Tanaka, Julio F M Marchini, Thaís Guimarães, Ester Sabino, Tarcisio E P Barros-Filho, Celina Almeida Lamas, João Marcos Salge, Cesar Higa Nomura, Adriana L Araújo, Bruno F Guedes, Carolina S Lázari, Cassiano C Antonio, Claudia C Leite, Emmanuel A Burdmann, Euripedes C Miguel, Fabio R Pinna, Geraldo F Busatto, Giovanni G Cerri, Heraldo P Souza, Izabel C Rios, Larissa S Oliveira, Linamara R Batisttella, Marcello M C Magri, Maura S Oliveira, Orestes V Forlenza, Ricardo F Bento, Rodolfo F Damiano, Rossana P Francisco, Wilson J Filho, Mateus Satoru Kajiwara, Luis Augusto Visani de Luna, Thais Suemi Yokoyama, Pedro Rizzi de Oliveira, Maria Amelia de Jesus, Vilson C Junior

“…Introduction Post-COVID-19 conditions (PCC) may include pulmonary sequelae, fatigue and other symptoms, but its mechanisms are not fully elucidated.Objective This study investigated the correlation between fatigue and the presence of pulmonary abnormalities in PCC patients with respiratory involvement 6–12 months after hospitalisation.Design Cross-sectional study.Setting A tertiary hospital in Brazil.Participants 315 patients, aged ≥18 years, were considered eligible based on SARS-CoV-2 infection confirmed by reverse transcription-PCR.Methods Pulmonary function tests (PFT), cardiopulmonary exercise tests (CPET), chest CT and hand grip were performed. …”
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Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs Densidade mineral óssea e níveis séricos de 25 OH vitamina D em usuários crônicos d... by Carolina A.M. Kulak, Victória Z.C. Borba, John P. Bilezikian, Carlos E. Silvado, Luciano de Paola, César L. Boguszewski

“…Blood samples were collected for total serum calcium, albumin, phosphorus, creatinine, total alkaline phosphatase, and liver function tests. BMD of the lumbar spine, femur and forearm was determined by dual energy X-ray absorptiometry (DXA, Hologic QDR 1000). …”
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Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study by Joan B Soriano, Juan José Soler-Cataluña, Marc Miravitlles, Julio Ancochea, Elena García Castillo, Miguel Barrueco Ferrero, Begoña Gallego, Ramon Fernandez, Inmaculada Alfageme, Borja G Cosío, Cristina Represas, Pilar de Lucas, Ciro Casanova, Francisco García-Río, José Miguel Rodríguez González-Moro, María Guadalupe Sánchez Herrero, Claudia Valenzuela, Ana Pueyo Bastida, Lourdes Lázaro Asegurado, Luis Rodríguez Pascual, Mª José Mora, Luis Borderias Clau, Lourdes Arizón Mendoza, Sandra García, Juan AR Miranda, Julián Grande Gutiérrez, Jesús Agustín Manzano, Manuel González, Milagros Rosales, José AF Villar, Ana Priegue, Isabel Portela Ferreño, Cecilia Mouronte Roibás, Sara Fernández García, Rocío Cordova Díaz, Nuria Toledo Pons, Margalida Llabrés, José MM Trigo, Marta Forner, Pablo Cubero, Elisabet Vera, Mª BP Albero, Noelia González García, Agustín Valido Morales, Carolina Panadero, Cristina Benito Bernáldez, Maria Velarde, Antonio Santa Cruz Siminiani, Carlos Castillo Quintanilla, Rocío Ibáñez Meléndez, José JM Garcerán, Desirée Lozano Vicente, Pedro García Torres, Maria del Mar Valdivia, Juan PT Tajes, Montserrat Cizur Girones, Carmen Labiano Turrillas, Carlos Ruiz Martínez, Elena Hernando, Elvira Alfaro, José Manuel García, Jorge Lázaro, David Bravo, Laura Hidalgo, Silvia Francisco Terreros, Iñaki Zorrilla, Ainara Alonso Colmenero, Cristina Martínez González, Susana Margon, Rosirys Guzman Taveras, Alicia Álvarez, José RA Balbín, Juan Agüero Calvo, Jaume Ferrer Sancho, Esther Rodríguez González, Eduardo Loeb, José LI Alonso, Mª AR García, Juan Abreu González, Candelaria Martín García, Rebeca Muñoz, Haydée Martín García, Miguel AM Muñiz, Andrés AS Antuña, Jesús Allende González, Jose AG Blanco, Fernando JA Navascues, Manuel AV Montes, María Rodríguez Pericacho, Concepción Rodríguez García, Juan DA Mavárez

“…The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.Methods A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. …”
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The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study by Michael K Stickland, Stephen Lam, Hasina Samji, Sarah Svenningsen, Rachel L Eddy, Don D Sin, Rafael Meza, Xuan Li, Jonathon Leipsic, Ana I Hernandez Cordero, Julia Yang, Theo J Moraes, Joanna MacLean, Shawn Aaron, Jonathan H Rayment, Simon Couillard, Terence Ho, Clarus Leung, Laura L Struik, Heather Drew, Paloma Burns, Satvir S Dhillon, Jordan Guenette, Trisha Tulloch, Tina Afshar, Brandon Zanette, Giles Santyr, François-Pierre Counil, Sheila Matano, Giulia de Arruda Maluf, Carmen Feng, Lydia Bal, Harnoor Dhaliwal, Adeola Mumuni, Caitlyn Lui, Janice M Leung

“…Participants will undergo respiratory questionnaires, pulmonary function tests, oscillometry, cardiopulmonary exercise testing, hyperpolarised 129-xenon gas MRI and blood collection. …”
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Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. II. Binary Star Modeling, Planet and Exozodi Search, and Sensitivity Analysis by Aniket Sanghi, Charles Beichman, Dimitri Mawet, William O. Balmer, Nicolas Godoy, Laurent Pueyo, Anthony Boccaletti, Max Sommer, Alexis Bidot, Elodie Choquet, Pierre Kervella, Pierre-Olivier Lagage, Jarron Leisenring, Jorge Llop-Sayson, Michael Ressler, Kevin Wagner, Mark Wyatt

“…We perform PSF injection–recovery tests and provide 2D sensitivity maps for each epoch to enable orbital completeness calculations. …”
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The effect of age and sex on brain metabolites: from childhood to adulthood by María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes

“…This cross-sectional study set out to examine the relationship between levels of neurometabolites and age and sex —key modulators of brain function and structure—, continuously from childhood to early adulthood, in areas relevant to the study of psychiatric disorders.Magnetic resonance spectroscopy (¹H MRS) data was acquired in the dorsomedial prefrontal region (dmPF) and the medial temporal lobe (mTL) in 128 healthy individuals aged 7 to 34 years, 68.5 % females (ndmPF = 124; nmTL = 75). …”
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Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…They accounted for over 23 million lost workdays annually and consume a significant amount of the health budget (approximately £5 billion per annum is spent by NHS England). Year on year, there continue to be unprecedented numbers of consultations in primary care; between 20% and 30% are related to MSKDs. …”
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[Artículo traducido] Análisis Rasch del índice de calidad de vida en dermatología by G. Sanclemente, C. Mora-Gaviria, D.C. Aguirre-Acevedo

“…Results: Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. …”
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