Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction by Tony Li, Vinay B. Panday, Jessele Lai, Nicholas Gao, Beth Lim, Aloysius Leow, Sarah Tan, Quek Swee Chye, Ching Hui Sia, William Kong, Tiong Cheng Yeo, Ru San Tan, Liang Zhong, Kian Keong Poh

“…Introduction: Assessment of left ventricular (LV) systolic function is important in valvular heart disease. The global LV contractility index, <i>dσ*/dt_max</i>, is load-independent and has been reported to be associated with clinical outcomes in heart failure and aortic stenosis. …”
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Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study by Adeline Ruyssen-Witrand, Jacques-Eric Gottenberg, Philippe Dieude, Rene-Marc Flipo, Jerome Avouac, Emanuelle Dernis, Anne Tournadre, Marie-Elise Truchetet, Raphaele Seror, André Ramon, Nicolas Roux, André Basch, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Pierre-Antoine Juge, Thao Pham, Clément Prati, Olivier Brocq, Jean Hugues Salmon, Christian hubert roux, Félicien Triboulet, Charles Leské, Émilie Shipley

“…Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.Results We enrolled 42 patients (26 women, 62%) with RA-ILD with a mean age of 61±13 years and a mean disease duration of 16±10 years. …”
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Predictors of probable sarcopenia and sarcopenia in older adults under outpatient geriatric care by Hérika Maria Silveira Ruas, Luciana Mara Barbosa Pereira, Carla Dayane Durães Abreu, Yara Cristina de Paiva Maia, Eli Carlos Pereira de Jesus, Luciana Colares Maia, Renato Sobral Monteiro-Junior, Sérgio Henrique Sousa Santos, Desirée Sant'Ana Haikal, Alfredo Maurício Batista de Paula

“…Methods: This cross-sectional study analyzed 511 Brazilian older adults (mean age=75.9±8.0 years, male-to-female ratio=1:1.62) followed at a public outpatient geriatrics clinic. …”
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In vitro mechanistic studies and potential health benefits of a standardized bilberry extract in low mood and cognitive enhancement by Mehtap Kara, Gozde Hasbal-Celikok, Jacob Wilson, Pilar Gómez-Serranillos, Tugba Yilmaz-Ozden, Ezgi Öztas, Gul Özhan, Özge Sultan Zengin, Marta Sánchez Gómez-Serranillos, Claudia Owsianik, Fazle Rabbani, Merve Tunç, Nazlı Arda, Nazia M. Memon, Ikram Ujjan, Kenny Hawkins, Justine Davis, Gabriel Wilson, Giovanna Petrangolini, Amjad Khan, Amjad Khan

“…A randomized, double-blind, placebo-controlled pilot clinical study was conducted on healthy adult subjects (n = 33) (aged 25–55 years) to evaluate the effects of Bilberry extract on mood (POMS) and cognitive function.ResultsBilberry extract demonstrated significant inhibition of GABA-T, MAO-A, and AChE, alongside moderate GABAA receptor binding. …”
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Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease by Rui Wang, Yuanyuan Li, Yuting Jiang, Xiaona Liu, Hongqi Feng, Zhe Jiao, Bingyun Li, Chang Liu, Yuncheng Shen, Fang Chu, Chenpeng Zhu, Dianjun Sun, Wei Zhang

“…Face-to-face interviews, lung function tests, and multiplex polymerase chain reaction were used to obtain data. …”
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A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV. by Krisann K Oursler, John D Sorkin, Alice S Ryan, Leslie I Katzel

“…Primary outcome was cardiorespiratory fitness (VO2peak) measured by treadmill testing. Secondary outcomes were exercise endurance, six-minute walk distance (6-MWD), body composition measured by Dual-energy X-ray absorptiometry (DXA), and fasting plasma levels of lipids and glucose.…”
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New Minimally Invasive Method for Treating Posterior Pelvic Ring Fractures: Biomechanical Validation and Clinical Application of Sacroiliac Joint Locking Plate by Liang Jin, Xiaorui Hao, Zhenzhu Zhang, Qiaoli Zhang, Shuxin Zhang, Fei Zhou, Shuirong Yang, Weijie Zheng, Xiaohui Xiong, Wanchen Gong, Yukun Wang, Xiaojie Chen, Jiexin Huang

“…A retrospective clinical study analyzed the clinical efficacy of SJP treatment in 62 patients (mean age of 51.7 ± 11.9 years and male‐to‐female ratio of 42/20) treated at our hospital from October 2016 to January 2023. …”
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s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight by K. V. Zhdanov, A. V. Semenov, S. S. Karyakin, K. V. Kozlov, V. S. Sukachev, Yu. V. Ostankova, D. E. Valutite, E. B. Zueva, R. S. Sidorov, A. V. Saulevich, Yu. I. Bulan’kov, Yu. I. Lyashenko, K. S. Ivanov

“…The functional condition of intestines was estimated by identification of a small intestinal bacterial overgrowth (SIBO) when carrying out the hydrogen respiratory test (HRT) with lactulose and existence of endoscopic signs of inflammation of a mucous membrane of intestines at a fibroezofagogastroduodenoskopiya. …”
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SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil by Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhaes de Oliveira, Larissa Rangel Mageste, Karin Nielsen-Saines, Patricia Brasil

“…SARS CoV-2 vertical transmission was observed in 6 of 169 (3.6%) tested neonates. Preterm deliveries occurred more frequently in patients testing positive for SARS-CoV-2 (30.7% vs. 23.6). …”
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Spectrum of mutations and their phenotypic manifestations in children and adults with long QT syndrome by N. N. Chakova, S. M. Komissarova, E. A. Zasim, T. V. Dolmatovich, E. S. Rebeko, S. S. Niyazova, E. V. Zaklyazminskaya, L. I. Plashchinskaya, M. V. Dudko

“…Variants with unknown clinical significance were identified in 4 probands (11%), which potentially allowed to confirm the diagnosis after functional tests.…”
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Psychometric properties of the Portuguese version of the Personality Assessment Inventory by Mauro Paulino, Mauro Paulino, Mauro Paulino, Mariana Moniz, Mariana Moniz, Octávio Moura, Octávio Moura, Daniel Rijo, Daniel Rijo, Leslie C. Morey, Mário R. Simões, Mário R. Simões, Mário R. Simões

“…., number of scales included in the factor analysis, validity criteria, factor analysis techniques, and estimators).MethodsThe present study aimed to investigate the factor structure of the Portuguese version of the PAI in a sample of 900 participants (aged 18–74 years, 57.7% female). Following the methodology proposed by other PAI factor analytic studies, we first conducted a CFA at the item level, for each individual scale, to test the unidimensionality of the 22 scales. …”
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PULMONARY-RENAL SYNDROME: DIFFICULTIES OF DIFFERENTIAL DIAGNOSIS by D. Yu. Andriyashkina, N. A. Demidova, N. A. Shostak, N. A. Tutaev, A. D. Ershov, D. K. Dudin

“…The study objective is to demonstrate the difficulty of differential diagnosis in pulmonary-renal syndrome using a clinical case as an example.Materials and methods. Male patient A., 68 years old, retired, was hospitalized at the N.I. …”
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Groundwater ammonia-oxidizing bacteria distribution and the correlations between the distribution and environmental factors around livestock lagoons by REN Juan, ZHANG Lei, ZENG Lingzao, WU Laosheng, SHI Jiachun

“…The result of No. 2 was built nearly half a year later than No. 1 and had a less stable boundary condition. …”
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Revisión de artrodesis subtalar por no unión: a propósito de un caso by Gregorio Verschae, MD, Valentín Val, MD, Vicente Alba, MD, Andrés Cáceres, MD, Sebastián Pavez, MD, Nicolás Cid, MD

“…Finally, the implementation of well-structured diagnostic and therapeutic algorithms is crucial to improve functional outcomes and ensure successful bone fusion.…”
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PD-1/PD-L1 Axis Downregulation in Guillain-Barré Syndrome: A Potential Mechanism Driving the Autoimmune Pathogenesis by Mr Rasel Ahmed, Mrs Israt Jahan, Mrs Pritha Biswash, Miss Mehjabeen Haque, Miss Sarah Khurshid, Mr Jigishu Ahmed, Mr Sayed Akib Hossain, Dr Zhahirul Islam

“…Results: In this cohort, the median age of GBS patients was 31 years (IQR:18-43), where 22 patients were male. Twenty-one patients were reported with antecedent events, primarily diarrhea (n=10), followed by fever (n=6), and common cold (n=5). …”
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Endothelial activation and stress index is a reliable predictor for the prevalence and mortality outcomes of stroke by Yongwei Huang, Zongping Li, Jianjun Wang, Decai Wang, Xiaoshuang Yin

“…The EASIX demonstrated a positive non-linear association with the prevalence and mortality outcomes amongst individuals at the age of 20 years and older who experienced a stroke, as identified in the NHANES dataset. …”
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Current opportunities to improve outcomes of COVID-19 infection prevention and course in patients with lymphoproliferative diseases (regional analysis) by Ch. Kh. Valiakhmetova, E. I. Siraeva

“…The effectiveness of vaccines may be reduced in people with compromised immune system function. Sequential vaccination does not ensure the production of sufficient antibodies in patients with hematological malignancies. …”
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The Combined Effect of Garlic (Allium sativum) and Turmeric (Curcuma longa) Extracts to Reduce the Adverse Effects of Aflatoxin B1 in Rats by Hadi Sarir, Saeedeh Zakerian, masood didarkhah

“…The use of garlic, turmeric extract, and their combination improves liver function indicators and reduces liver enzymes such as AST, ALT, ALP, and total bilirubin. …”
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Effectiveness of Group Problem Management Plus, a brief psychological intervention for adults affected by humanitarian disasters in Nepal: A cluster randomized controlled trial. by Mark J D Jordans, Brandon A Kohrt, Manaswi Sangraula, Elizabeth L Turner, Xueqi Wang, Pragya Shrestha, Renasha Ghimire, Edith Van't Hof, Richard A Bryant, Katie S Dawson, Kedar Marahatta, Nagendra P Luitel, Mark van Ommeren

“…Eligible participants were adult women and men 18 years of age and older who met screening criteria for psychological distress and functional impairment. …”
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Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II) by Valentin Max Vetter, Kamil Demircan, Jan Homann, Thilo Samson Chillon, Michael Mülleder, Orr Shomroni, Elisabeth Steinhagen-Thiessen, Markus Ralser, Christina M. Lill, Lars Bertram, Lutz Schomburg, Ilja Demuth

“…Abstract Background Biological age reflects inter-individual differences in biological function and capacity beyond chronological age. DNA methylation age (DNAmA) and its deviation from chronological age, DNAmA acceleration (DNAmAA), which was calculated as residuals of leukocyte cell count adjusted linear regression of DNAmA on chronological age, were used to estimate biological age in this study. …”
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