Clinical characteristics, outcomes, and predictive modeling of patients diagnosed with immune checkpoint inhibitor therapy-related pneumonitis by Antonious Hazim, Irene Riestra Guiance, Jacob Shreve, Gordon Ruan, Damian McGlothlin, Allison LeMahieu, Robert Haemmerle, Keith Mcconn, Richard C. Godby, Lisa Kottschade, Anna Schwecke, Casey Fazer-Posorske, Tobias Peikert, Eric Edell, Konstantinos Leventakos, Ashley Egan

“…Risk of death from ICI pneumonitis prior to starting immunotherapy was modeled with an area under the curve of the receiver operator characteristic (AUC-ROC) of 0.79 with the most contributory features including peripheral blood lymphocyte count, oxygen dependence, pulmonary function testing, and PD-L1 expression. Conclusion The presentation of ICI pneumonitis is highly variable, and outcomes are dependent on severity, but favor grade 2 disease when patients are rechallenged with immunotherapy. …”
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Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning by Jiayuan Xu, Andrew J. Doig, Sofia Michopoulou, Sofia Michopoulou, Petroula Proitsi, Petroula Proitsi, Fumie Costen, The Alzheimer's disease neuroimaging initiative

“…BackgroundAlzheimer's disease (AD) greatly affects the daily functioning and life quality of patients and is prevalent in the elderly population. …”
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Fibromyalgia Patients Have Markedly Greater Postoperative Opioid Use and Emergency Department Visits Following Bunionectomy by Andrew Sauer BA, Jung Yoo MD, Lara Atwater MD

“…Fibromyalgia patients were compared to those without a diagnosis using Chi-squared tests for categorical variables and independent t-tests for continuous variables. …”
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Young Scientists’ Motivation for the Research Activity in Russian Regional Universities by R. A. Dolzhenko, V. A. Karpilianskii, R. A. Hady, A. S. Didenko

“…The cluster sampling involved 148 young scientists (Doctors of Sciences under 40 years old, Candidates of Sciences under 35 years old, postgraduate students and researchers without a degree under 30 years old). …”
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The effect of lifestyle on late-life cognitive change under different socioeconomic status. by Pei-Hsuan Weng, Jen-Hau Chen, Jeng-Min Chiou, Yu-Kang Tu, Ta-Fu Chen, Ming-Jang Chiu, Sung-Chun Tang, Shin-Joe Yeh, Yen-Ching Chen

“…Neuropsychological tests, including tests of global cognition, logical memory, executive function, verbal fluency and attention, were administered at baseline (N = 603) and 2 years later (N = 509). …”
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The Prognostic Implication of Left Atrial Strain Parameters with Conventional Left Atrial Parameters for the Prediction of Adverse Outcomes in Asian Patients with Hypertrophic Card... by Andre Seah, Tony Y. W. Li, Novi Yanti Sari, Chi-Hang Lee, Tiong-Cheng Yeo, James W. L. Yip, Yoke Ching Lim, Kian-Keong Poh, William K. F. Kong, Weiqin Lin, Ching-Hui Sia, Raymond C. C. Wong

“…Background/Objectives: Left atrial function can be a tool for risk stratification for hypertrophic cardiomyopathy (HCM). …”
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Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial by Nagore Iriarte-Yoller, José Etxaniz-Oses, Cristobal Pavón-Navajas, Mikel Tous-Espelosin, Pedro M. Sánchez-Gómez, Sara Maldonado-Martín, Ana B. Yoller-Elburgo, Edorta Elizagarate-Zabala

“…Secondary outcome variables will include cardiorespiratory fitness (peak oxygen uptake through peak cardiopulmonary exercise test), body composition (bioimpedance and anthropometric variables), physical activity level (the International Physical Activity Questionnaire), health-related quality of life (the Short Form-36 Health Survey), functional outcome (the Sheehan Disability Scale and Quality of Life in Depression Scale), overall disease severity (the Clinical Global Impression Scale-Severity of Illness), and biochemical variables (a fasting blood sample). …”
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Evolution of an Artificial Intelligence-Powered Application for Mammography by Yuriy Vasilev, Denis Rumyantsev, Anton Vladzymyrskyy, Olga Omelyanskaya, Lev Pestrenin, Igor Shulkin, Evgeniy Nikitin, Artem Kapninskiy, Kirill Arzamasov

“…The methodology encompassed functional and calibration testing, coupled with routine technical and clinical monitoring. …”
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Genetic passport as a basis for primary and secondary prevention of cerebral infarction in young people by T. I. Dutova, I. N. Banin, N. A. Ermolenko

“…Venous blood tests were once performed in all the subjects to reveal genetic polymorphisms of the hemostasis system, the immune response, the endothelial function, and the lipid metabolism. …”
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The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study by Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang

“…Pearson correlation tests were used to explore the correlations of the parameters of actigraphy and HRV with prognosis. …”
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Development of Non-Genetic Risk Stratification Model of Severe Allopurinol Hypersensitivity (NoG-ALLOH Score): A Multicenter Study in Thailand by Patapong Towiwat, Suppachai Lawanaskol, Wichittra Tassaneeyakul, Chonlaphat Sukasem, Niwat Saksit, Nontaya Nakkam, Duangkamon Poolpun, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Worawit Louthrenoo

“…Although HLA-B*58:01 testing is recommended in Thai, the several problems including cost, limitation of the testing and the delay of the result. …”
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Diagnostic accuracy of apoptosis markers in non-alcoholic fatty liver disease in children by Yu. M. Stepanov, N. Yu. Zavhorodnia, O. Yu. Zavhorodnia, V. B. Yahmur, O. M. Tatarchuk, O. P. Petishko

“…Early diagnosis of rapidly progressive forms of NAFLD – non-alcoholic steatohepatitis (NASH) – is crucial, because therapeutic intervention in the early disease stages creates unique opportunities for the reversal of pathological changes and restoration of liver structure and function. Despite the variety of currently available diagnostic scales and indices, laboratory diagnosis of NAFLD in children requires new non-invasive tests and their validation. …”
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CELL THERAPY OF EPILEPSIA. CLINICAL AND IMMUNOLOGICAL ASPECTS by T. V. Dokukina, M. P. Potapnev, S. M. Kosmacheva, F. P. Hlebokazov, E. L. Slobina, T. S. Golubeva, N. N. Misjuk, M. V. Mahrov, I. V. Shamruk, P. P. Korolevich, A. I. Martynenko, I. V. Bychenko, T. O. Bud’ko

“…The patient age varied from 23 to 46 years; and the duration of epilepsy was 7-29 years. …”
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Defining surgical indications in subcoracoid cysts: 3D volumetric analysis and elastography guide tendon-preserving arthroscopic decompression by Halil Ibrahim Arikan, Bekir Eray Kilinc, Ahmet Vural, Ahmet Nedim Kahraman

“…Abstract Background This prospective cohort study evaluates the impact of arthroscopic subcoracoid cyst decompression on subscapularis tendon elasticity and functional outcomes, while defining prognostic thresholds for surgical decision-making. …”
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Haplotype-resolved genome reveals haplotypic variation and the biosynthesis of medicinal ingredients in Areca catechu L. by Chao Wang, Lei Tan, Zhonghui Zhang, Xianggui Li, Linghao Xia, Peng Cao, Haiyang Tong, Xumin Ou, Shixuan Li, Jianing Zhang, Chun Li, Jun Yang, Wen-Biao Jiao, Shouchuang Wang

“…AcGNMT1, AcGNMT2 and their three homologous genes were involved in the conversion of guvacine to arecoline. Further analyses tested the function of AcUGT71CE15, AcUGT74CJ38, AcUGT87EE5 and AcUGT83S982 as glucosyltransferases, and AcUGT78AP14 was identified as a rhamnosyltransferase involved in flavonol glycosylation. …”
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Psychometric properties of the EQ-5D-5L in diabetes mellitus patients in Spain by Amaia Bilbao-González, Marta González-Sáenz de Tejada, Montse Ferrer, Yolanda Ramallo-Fariña, Miguel Paja-Fano, Carlos García-Forero, Daniela Mestre, Iñigo Gorostiza-Hormaetxe

“…The reliability was assessed by Cronbach’s alpha, and the item functioning by the item response theory (IRT). Convergent validity was tested using the Spearman correlation coefficient between EQ-5D-5L, ADDQoL, HADS and the general health question. …”
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Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Associated exacerbations and declining lung function contribute to increasing disability and mortality. …”
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Plain radiograph evaluation of concurrent filling of tibial peg holes with bone in cementless total knee arthroplasty by Kazue Hayakawa, Hideki Date, Sho Nojiri, Yosuke Kaneko, Kohei Shibata, Nobuyuki Fujita

“…Results: The mean follow-up period was 5 years and 5 months. Knee Society Scores and Knee Society Functional Scores did not differ significantly between groups; however, the bone filling group had a significantly lower incidence of RLLs (p ​< ​0.05) and significantly more longitudinal trabecular thickening below the pegs (p ​< ​0.05). …”
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Plasma and MRI biomarkers capture neuronal damage in former professional boxers by Suzie Kamps, Suzan van Amerongen, Elena R. Blujdea, Marloes I. Hoppen, Bram Bongers, Kasper H. Schelvis, Dewi K. Caton, Marsh Königs, Charlotte E. Teunissen, Philip Scheltens, Rik Ossenkoppele, Everard G. B. Vijverberg

“…Cognitive performance was assessed in memory and executive functioning (EF) domains. Five boxers had follow-up measurements after ~ 7 years. …”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…In the testing phase (phase 2), the initial full prototype of the digital intervention was piloted with patients (n=11; aged 36-58 years; 9/11, 82% women; with diverse diagnoses, including migraine, arthritis, fibromyalgia, complex regional pain syndrome, hypermobile Ehlers-Danlos syndrome, herniated disc, chronic fatigue syndrome, and 1/11, 9% cases of undiagnosed pain) and therapists (n=3 licensed psychologists; aged 36-58 y; 3/3, 100% women). …”
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